HitPredict

Interactor 1: 1433Z (P63104)
14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)
Gene: YWHAZ

Interactor 2: ZO1 (Q07157)
Tight junction protein ZO-1 (Tight junction protein 1) (Zona occludens protein 1) (Zonula occludens protein 1)
Gene: TJP1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	36931259
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0043066 - negative regulation of apoptotic process GO:0045296 - cadherin binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Hs			1 1748
+	Hs
		646827 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		ZO1_HUMAN (1-1748): 0: 925: 100.00
+	Hs
		683290 1433B_HUMAN (1-242): 9.01e-140: 393: 87.60		ZO1_HUMAN (1-1748): 0: 925: 100.00
+	Hs
		159186 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		CSKP_HUMAN (217-806): 6.5e-86: 305: 14.66
+	Mm
		926805 1433Z_MOUSE (1-245): 3.48e-145: 407: 99.59		DLG4_MOUSE (1-112): 2.37e-27: 122: 29.92
+	Mm
		910260 1433E_MOUSE (2-241): 9.9e-144: 403: 68.18		DLG4_MOUSE (1-112): 2.37e-27: 122: 29.92
+	Dm
		664599 1433Z_DROME (1-245): 3.35e-143: 402: 81.22		DLG1_DROME (1-118): 1.51e-24: 114: 25.00
+	Dm
		677686 1433E_DROME (2-242): 3.33e-143: 402: 66.67		DLG1_DROME (1-118): 1.51e-24: 114: 25.00
+	Hs
		926984 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		PTN13_HUMAN (20-492): 4.02e-23: 110: 16.63
+	Hs
		909498 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		PTN13_HUMAN (20-492): 4.02e-23: 110: 16.63
+	Hs
		646848 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		PTN13_HUMAN (20-492): 4.02e-23: 110: 16.63
+	Hs
		683305 1433B_HUMAN (1-242): 9.01e-140: 393: 87.60		PTN13_HUMAN (20-492): 4.02e-23: 110: 16.63
+	Hs
		927332 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		DLG5_HUMAN (262-508): 3.83e-17: 90.3: 21.43
+	Hs
		909845 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		DLG5_HUMAN (262-508): 3.83e-17: 90.3: 21.43
+	Mm
		1143489 1433B_MOUSE (1-242): 3.77e-128: 364: 87.19		DLG4_MOUSE (1-112): 2.37e-27: 122: 29.92
+	Hs
		647130 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		DLG5_HUMAN (262-508): 3.83e-17: 90.3: 21.43
+	Hs
		683563 1433B_HUMAN (1-242): 9.01e-140: 393: 87.60		DLG5_HUMAN (262-508): 3.83e-17: 90.3: 21.43
+	Hs
		927623 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		ZO2_HUMAN (391-610): 1e-09: 65.7: 17.98
+	Hs
		910124 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		ZO2_HUMAN (391-610): 1e-09: 65.7: 17.98
+	Hs
		647357 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		ZO2_HUMAN (391-610): 1e-09: 65.7: 17.98
+	Hs
		683788 1433B_HUMAN (1-242): 9.01e-140: 393: 87.60		ZO2_HUMAN (391-610): 1e-09: 65.7: 17.98