HitPredict

Interactor 1: 1433Z (P63104)
14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)
Gene: YWHAZ

Interactor 2: RGPS2 (Q86X27)
Ras-specific guanine nucleotide-releasing factor RalGPS2 (Ral GEF with PH domain and SH3-binding motif 2) (RalA exchange factor RalGPS2)
Gene: RALGPS2

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.91	0.60	0.739

Property	Details
Experiments	28514442, 33961781, 17353931, 35271311, 36931259, 15324660
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Hs			1 583
+	Hs
		909770 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		RGPS2_HUMAN (1-583): 0: 643: 100.00
+	Hs
		647073 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		RGPS2_HUMAN (1-583): 0: 643: 100.00
+	Hs
		683515 1433B_HUMAN (1-242): 9.01e-140: 393: 87.60		RGPS2_HUMAN (1-583): 0: 643: 100.00
+	Hs
		904810 1433G_HUMAN (1-240): 2.37e-108: 314: 74.59		RGPS2_HUMAN (1-583): 0: 643: 100.00
+	Hs
		647081 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		GRP3_HUMAN (2-480): 8.48e-121: 374: 21.15
+	Hs
		927702 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		RPGF2_HUMAN (18-474): 8.7e-102: 339: 17.58
+	Hs
		910200 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		RPGF2_HUMAN (18-474): 8.7e-102: 339: 17.58
+	Mm
		926845 1433Z_MOUSE (1-245): 3.48e-145: 407: 99.59		RPGF2_MOUSE (18-474): 1.88e-98: 329: 17.58
+	Hs
		647416 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		RPGF2_HUMAN (18-474): 8.7e-102: 339: 17.58
+	Hs
		683851 1433B_HUMAN (1-242): 9.01e-140: 393: 87.60		RPGF2_HUMAN (18-474): 8.7e-102: 339: 17.58
+	Hs
		171544 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		RGL2_HUMAN (26-480): 5.4e-102: 327: 20.83
+	Hs
		927336 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		RPGF6_HUMAN (18-462): 3.55e-96: 323: 15.79
+	Hs
		909851 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		RPGF6_HUMAN (18-462): 3.55e-96: 323: 15.79
+	Hs
		171537 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		RGL2_HUMAN (26-480): 5.4e-102: 327: 20.83
+	Hs
		171538 1433B_HUMAN (1-242): 9.01e-140: 393: 87.60		RGL2_HUMAN (26-480): 5.4e-102: 327: 20.83
+	Hs
		647134 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		RPGF6_HUMAN (18-462): 3.55e-96: 323: 15.79
+	Hs
		683569 1433B_HUMAN (1-242): 9.01e-140: 393: 87.60		RPGF6_HUMAN (18-462): 3.55e-96: 323: 15.79
+	Mm
		926773 1433Z_MOUSE (1-245): 3.48e-145: 407: 99.59		RGRF2_MOUSE (6-290): 1.89e-90: 304: 29.02
+	Hs
		683335 1433B_HUMAN (1-242): 9.01e-140: 393: 87.60		RGRF1_HUMAN (6-290): 2.79e-89: 302: 28.67
+	Hs
		171542 1433G_HUMAN (1-240): 2.37e-108: 314: 74.59		RGL2_HUMAN (26-480): 5.4e-102: 327: 20.83