HitPredict

Interactor 1: 1433Z (P63104)
14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)
Gene: YWHAZ

Interactor 2: MADD (Q8WXG6)
MAP kinase-activating death domain protein (Differentially expressed in normal and neoplastic cells) (Insulinoma glucagonoma clone 20) (Rab3 GDP/GTP exchange factor) (RabGEF) (Rab3 GDP/GTP exchange protein) (Rab3GEP)
Gene: MADD

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.57	0.60	0.586

Property	Details
Experiments	20936779, 16959763
Identification Methods	two hybrid, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Hs			1 1647
+	Mm
		926828 1433Z_MOUSE (1-245): 3.48e-145: 407: 99.59		MADD_MOUSE (1-1576): 0: 2240: 95.31
+	Hs
		927152 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		DEN4C_HUMAN (14-685): 2.29e-131: 454: 20.32
+	Hs
		909665 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		DEN4C_HUMAN (14-685): 2.29e-131: 454: 20.32
+	Hs
		646988 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		DEN4C_HUMAN (14-685): 2.29e-131: 454: 20.32
+	Mm
		926821 1433Z_MOUSE (1-245): 3.48e-145: 407: 99.59		MTMR5_MOUSE (10-658): 5.12e-127: 440: 19.76
+	Hs
		309464 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		MTMR5_HUMAN (10-658): 1.04e-126: 440: 20.21
+	Hs
		309444 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		MTMR5_HUMAN (10-658): 1.04e-126: 440: 20.21
+	Hs
		927224 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		MYCPP_HUMAN (14-685): 2.34e-123: 430: 18.58
+	Hs
		909741 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		MYCPP_HUMAN (14-685): 2.34e-123: 430: 18.58
+	Hs
		647051 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		MYCPP_HUMAN (14-685): 2.34e-123: 430: 18.58
+	Hs
		927335 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		DEN1A_HUMAN (106-772): 1.72e-93: 329: 15.00
+	Hs
		909848 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		DEN1A_HUMAN (106-772): 1.72e-93: 329: 15.00
+	Hs
		926916 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		DEN2B_HUMAN (82-548): 7.53e-90: 320: 17.14
+	Hs
		647133 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		DEN1A_HUMAN (106-772): 1.72e-93: 329: 15.00
+	Hs
		909436 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		DEN2B_HUMAN (82-548): 7.53e-90: 320: 17.14
+	Hs
		646993 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		DEN2C_HUMAN (99-548): 1.26e-92: 324: 17.02
+	Hs
		646791 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		DEN2B_HUMAN (82-548): 7.53e-90: 320: 17.14
+	Hs
		927176 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		DEN1B_HUMAN (85-607): 1.5e-75: 270: 15.06
+	Hs
		909687 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		DEN1B_HUMAN (85-607): 1.5e-75: 270: 15.06
+	Hs
		647009 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		DEN1B_HUMAN (85-607): 1.5e-75: 270: 15.06