HitPredict

Interactor 1: 1433Z (P63104)
14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)
Gene: YWHAZ

Interactor 2: MARK4 (Q96L34)
MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1)
Gene: MARK4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	35271311, 16306228
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006468 - protein phosphorylation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Hs			1 752
+	Hs
		909916 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		MARK4_HUMAN (1-752): 0: 733: 100.00
+	Mm
		910308 1433E_MOUSE (2-241): 9.9e-144: 403: 68.18		MARK4_MOUSE (1-752): 0: 731: 97.61
+	Mm
		926780 1433Z_MOUSE (1-245): 3.48e-145: 407: 99.59		MARK3_MOUSE (1-752): 0: 700: 58.69
+	Hs
		647869 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		MARK3_HUMAN (1-752): 0: 701: 58.56
+	Hs
		647862 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		MARK3_HUMAN (1-752): 0: 701: 58.56
+	Mm
		910231 1433E_MOUSE (2-241): 9.9e-144: 403: 68.18		MARK3_MOUSE (1-752): 0: 700: 58.69
+	Mm
		910234 1433E_MOUSE (2-241): 9.9e-144: 403: 68.18		MARK2_MOUSE (2-752): 0: 641: 49.69
+	Hs
		927214 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		MARK2_HUMAN (2-752): 0: 639: 48.15
+	Hs
		909730 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		MARK2_HUMAN (2-752): 0: 639: 48.15
+	Hs
		927600 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		MARK1_HUMAN (1-752): 0: 632: 51.06
+	Mm
		910318 1433E_MOUSE (2-241): 9.9e-144: 403: 68.18		MARK1_MOUSE (1-752): 0: 631: 51.06
+	Hs
		927047 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		MELK_HUMAN (59-752): 1.3e-176: 522: 26.44
+	Hs
		909567 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		MELK_HUMAN (59-752): 1.3e-176: 522: 26.44
+	Mm
		910272 1433E_MOUSE (2-241): 9.9e-144: 403: 68.18		BRSK2_MOUSE (55-504): 8.46e-147: 448: 36.66
+	Hs
		909786 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		BRSK2_HUMAN (55-504): 2.77e-146: 447: 36.66
+	Hs
		883215 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		SIK1_HUMAN (37-662): 2.63e-142: 438: 33.74
+	Hs
		883214 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		SIK1_HUMAN (37-662): 2.63e-142: 438: 33.74
+	Hs
		927683 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		SIK3_HUMAN (56-367): 1.81e-109: 363: 59.32
+	Mm
		926816 1433Z_MOUSE (1-245): 3.48e-145: 407: 99.59		SIK3_MOUSE (56-367): 4.94e-108: 360: 58.70
+	Hs
		927511 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		SIK2_HUMAN (56-367): 5.39e-104: 341: 55.17