HitPredict

Interactor 1: 1433Z (P63104)
14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)
Gene: YWHAZ

Interactor 2: NEK1 (Q96PY6)
Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (Never in mitosis A-related kinase 1) (NimA-related protein kinase 1) (Renal carcinoma antigen NY-REN-55)
Gene: NEK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	35271311, 36931259
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006468 - protein phosphorylation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Hs			1 1258
+	Hs
		927145 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		MRCKA_HUMAN (2-901): 2.99e-144: 480: 19.19
+	Hs
		909524 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		ROCK1_HUMAN (2-1044): 4.42e-142: 467: 15.73
+	Mm
		926780 1433Z_MOUSE (1-245): 3.48e-145: 407: 99.59		MARK3_MOUSE (3-645): 1.73e-138: 441: 17.07
+	Hs
		927411 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		MARK4_HUMAN (3-644): 2.23e-138: 441: 16.56
+	Hs
		647869 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		MARK3_HUMAN (3-645): 1.72e-137: 439: 17.22
+	Mm
		910231 1433E_MOUSE (2-241): 9.9e-144: 403: 68.18		MARK3_MOUSE (3-645): 1.73e-138: 441: 17.07
+	Hs
		927214 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		MARK2_HUMAN (3-645): 3.79e-137: 439: 17.42
+	Hs
		647862 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		MARK3_HUMAN (3-645): 1.72e-137: 439: 17.22
+	Mm
		910308 1433E_MOUSE (2-241): 9.9e-144: 403: 68.18		MARK4_MOUSE (3-644): 1.03e-137: 439: 17.31
+	Mm
		910234 1433E_MOUSE (2-241): 9.9e-144: 403: 68.18		MARK2_MOUSE (3-645): 9.66e-137: 437: 17.26
+	Hs
		927511 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		SIK2_HUMAN (4-781): 8.83e-134: 434: 15.15
+	Hs
		871356 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		AAPK2_HUMAN (3-508): 9.05e-125: 398: 17.46
+	Hs
		871354 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		AAPK2_HUMAN (3-508): 9.05e-125: 398: 17.46
+	Hs
		681776 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		AKT1_HUMAN (1-316): 5.31e-119: 380: 27.41
+	Hs
		681770 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		AKT1_HUMAN (1-316): 5.31e-119: 380: 27.41
+	Mm
		926819 1433Z_MOUSE (1-245): 3.48e-145: 407: 99.59		KCC2D_MOUSE (2-281): 1.99e-112: 363: 28.82
+	Hs
		909532 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		KCC2D_HUMAN (2-281): 1.99e-112: 363: 28.82
+	Hs
		851437 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		NEK4_HUMAN (1-266): 1.31e-78: 279: 50.56
+	Hs
		851417 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		NEK4_HUMAN (1-266): 1.31e-78: 279: 50.56
+	Hs
		927164 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		MRCKG_HUMAN (503-882): 7.12e-12: 72.5: 12.00