HitPredict

Interactor 1: 1433Z (P63104)
14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)
Gene: YWHAZ

Interactor 2: M3K5 (Q99683)
Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 1) (ASK-1) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5)
Gene: MAP3K5

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.88	0.60	0.730

Property	Details
Experiments	25852190, 10411906, 29227477, 35271311, 15023544, 16449798
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, two hybrid, pull down, coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006468 - protein phosphorylation GO:0019901 - protein kinase binding GO:0019904 - protein domain specific binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Hs			1 1374
+	Hs
		927194 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		M3K15_HUMAN (27-1373): 0: 1202: 56.66
+	Hs
		312792 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		M3K6_HUMAN (27-1374): 0: 1171: 43.67
+	Hs
		312790 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		M3K6_HUMAN (27-1374): 0: 1171: 43.67
+	Mm
		926780 1433Z_MOUSE (1-245): 3.48e-145: 407: 99.59		MARK3_MOUSE (654-1374): 5.01e-158: 496: 15.98
+	Hs
		647869 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		MARK3_HUMAN (625-1374): 2.41e-158: 497: 15.81
+	Mm
		910231 1433E_MOUSE (2-241): 9.9e-144: 403: 68.18		MARK3_MOUSE (654-1374): 5.01e-158: 496: 15.98
+	Mm
		910234 1433E_MOUSE (2-241): 9.9e-144: 403: 68.18		MARK2_MOUSE (629-1374): 3.1e-151: 478: 13.72
+	Hs
		927214 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		MARK2_HUMAN (629-1374): 9.11e-149: 472: 14.03
+	Hs
		927600 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		MARK1_HUMAN (622-1374): 4.12e-143: 458: 15.27
+	Mm
		910318 1433E_MOUSE (2-241): 9.9e-144: 403: 68.18		MARK1_MOUSE (622-1374): 6.04e-143: 457: 15.39
+	Hs
		851437 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		NEK4_HUMAN (680-1303): 2.63e-113: 378: 19.70
+	Mm
		926866 1433Z_MOUSE (1-245): 3.48e-145: 407: 99.59		KCC2G_MOUSE (678-1086): 2.9e-112: 365: 22.80
+	Hs
		270395 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		KS6A5_HUMAN (673-1088): 5.06e-109: 365: 19.51
+	Mm
		926819 1433Z_MOUSE (1-245): 3.48e-145: 407: 99.59		KCC2D_MOUSE (678-995): 1.4e-97: 324: 26.53
+	Hs
		926996 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		PAK1_HUMAN (686-959): 2.31e-97: 325: 31.02
+	Hs
		131562 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		STK25_HUMAN (686-1026): 1.88e-97: 321: 31.29
+	Hs
		927454 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		M3K3_HUMAN (685-940): 1.87e-43: 171: 40.08
+	Hs
		927001 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		M3K1_HUMAN (686-933): 1.47e-40: 166: 37.31
+	Hs
		927688 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		M3K2_HUMAN (685-938): 1.31e-41: 165: 40.00
+	Hs
		681776 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		AKT1_HUMAN (438-615): 7.18e-25: 112: 13.64