HitPredict

Interactor 1: 1433Z (P63104)
14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)
Gene: YWHAZ

Interactor 2: ZO2 (Q9UDY2)
Tight junction protein ZO-2 (Tight junction protein 2) (Zona occludens protein 2) (Zonula occludens protein 2)
Gene: TJP2

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	17353931, 35271311, 15324660
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0019904 - protein domain specific binding GO:0044325 - transmembrane transporter binding and 1 others more... GO:0045296 - cadherin binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Hs			1 1190
+	Hs
		910124 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		ZO2_HUMAN (1-1190): 0: 838: 100.00
+	Hs
		647357 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		ZO2_HUMAN (1-1190): 0: 838: 100.00
+	Hs
		683788 1433B_HUMAN (1-242): 9.01e-140: 393: 87.60		ZO2_HUMAN (1-1190): 0: 838: 100.00
+	Hs
		905218 1433G_HUMAN (1-240): 2.37e-108: 314: 74.59		ZO2_HUMAN (1-1190): 0: 838: 100.00
+	Hs
		926961 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		ZO1_HUMAN (19-1187): 5.94e-133: 447: 36.80
+	Hs
		646827 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		ZO1_HUMAN (19-1187): 5.94e-133: 447: 36.80
+	Hs
		683290 1433B_HUMAN (1-242): 9.01e-140: 393: 87.60		ZO1_HUMAN (19-1187): 5.94e-133: 447: 36.80
+	Hs
		904480 1433G_HUMAN (1-240): 2.37e-108: 314: 74.59		ZO1_HUMAN (19-1187): 5.94e-133: 447: 36.80
+	Hs
		159186 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		CSKP_HUMAN (229-890): 6.3e-93: 321: 15.09
+	Mm
		926805 1433Z_MOUSE (1-245): 3.48e-145: 407: 99.59		DLG4_MOUSE (3-423): 3.16e-52: 198: 18.89
+	Mm
		910260 1433E_MOUSE (2-241): 9.9e-144: 403: 68.18		DLG4_MOUSE (3-423): 3.16e-52: 198: 18.89
+	Mm
		1143489 1433B_MOUSE (1-242): 3.77e-128: 364: 87.19		DLG4_MOUSE (3-423): 3.16e-52: 198: 18.89
+	Dm
		664599 1433Z_DROME (1-245): 3.35e-143: 402: 81.22		DLG1_DROME (12-421): 3.86e-35: 147: 17.36
+	Dm
		677686 1433E_DROME (2-242): 3.33e-143: 402: 66.67		DLG1_DROME (12-421): 3.86e-35: 147: 17.36
+	Mm
		905344 1433G_MOUSE (1-240): 2.37e-108: 314: 74.59		DLG4_MOUSE (3-423): 3.16e-52: 198: 18.89
+	Hs
		927332 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		DLG5_HUMAN (25-522): 2.43e-14: 80.4: 11.77
+	Hs
		909845 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		DLG5_HUMAN (25-522): 2.43e-14: 80.4: 11.77
+	Hs
		647130 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		DLG5_HUMAN (25-522): 2.43e-14: 80.4: 11.77
+	Hs
		683563 1433B_HUMAN (1-242): 9.01e-140: 393: 87.60		DLG5_HUMAN (25-522): 2.43e-14: 80.4: 11.77
+	Hs
		904899 1433G_HUMAN (1-240): 2.37e-108: 314: 74.59		DLG5_HUMAN (25-522): 2.43e-14: 80.4: 11.77