HitPredict

Interactor 1: 1433Z (P63104)
14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)
Gene: YWHAZ

Interactor 2: HECD1 (Q9ULT8)
E3 ubiquitin-protein ligase HECTD1 (EC 2.3.2.26) (E3 ligase for inhibin receptor) (EULIR) (HECT domain-containing protein 1)
Gene: HECTD1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.50	0.558

Property	Details
Experiments	35271311, 36931259
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Hs			1 2610
+	Hs
		910149 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		HECD1_HUMAN (1-2610): 0: 2419: 100.00
+	Mm
		808343 1433E_MOUSE (2-241): 9.9e-144: 403: 68.18		NEDD4_MOUSE (2258-2608): 9.66e-121: 407: 19.89
+	Rn
		910358 1433E_RAT (2-241): 9.9e-144: 403: 68.18		NEDD4_RAT (2258-2608): 4.01e-119: 403: 20.11
+	Hs
		927423 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		NED4L_HUMAN (2255-2608): 4.26e-117: 399: 21.67
+	Mm
		93264 1433E_MOUSE (2-241): 9.9e-144: 403: 68.18		E9PXB7_MOUSE (2255-2608): 3.94e-119: 401: 21.67
+	Hs
		909930 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		NED4L_HUMAN (2255-2608): 4.26e-117: 399: 21.67
+	Mm
		910302 1433E_MOUSE (2-241): 9.9e-144: 403: 68.18		NED4L_MOUSE (2255-2608): 2.21e-116: 398: 21.67
+	Hs
		647201 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		NED4L_HUMAN (2255-2608): 4.26e-117: 399: 21.67
+	Hs
		647191 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		ITCH_HUMAN (2234-2608): 3.18e-117: 398: 21.88
+	Hs
		647296 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		SMUF1_HUMAN (2220-2607): 1.5e-116: 391: 19.70
+	Hs
		125351 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		WWP2_HUMAN (2265-2608): 1.64e-107: 368: 24.86
+	Hs
		125318 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		WWP2_HUMAN (2265-2608): 1.64e-107: 368: 24.86
+	Hs
		125169 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		WWP2_HUMAN (2265-2608): 1.64e-107: 368: 24.86
+	Hs
		647267 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		WWP1_HUMAN (2328-2608): 5.47e-91: 321: 29.27
+	Hs
		927043 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		TRIPC_HUMAN (5-1083): 4.48e-58: 225: 14.03
+	Hs
		909564 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		TRIPC_HUMAN (5-1083): 4.48e-58: 225: 14.03
+	Hs
		646888 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		TRIPC_HUMAN (5-1083): 4.48e-58: 225: 14.03
+	Hs
		926955 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		UBE3A_HUMAN (2406-2607): 5.17e-25: 116: 34.95
+	Hs
		909468 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		UBE3A_HUMAN (2406-2607): 5.17e-25: 116: 34.95
+	At
		788566 14333_ARATH (3-239): 1.48e-141: 398: 64.73		UPL2_ARATH (2424-2604): 7.84e-20: 100: 34.60