HitPredict

Interactor 1: 1433Z (P63104)
14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)
Gene: YWHAZ

Interactor 2: FBW1A (Q9Y297)
F-box/WD repeat-containing protein 1A (E3RSIkappaB) (Epididymis tissue protein Li 2a) (F-box and WD repeats protein beta-TrCP) (pIkappaBalpha-E3 receptor subunit)
Gene: BTRC

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	25900982, 36199071
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Hs			1 605
+	Hs
		910177 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		FBW1A_HUMAN (1-605): 0: 551: 100.00
+	Hs
		647395 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		FBW1A_HUMAN (1-605): 0: 551: 100.00
+	Hs
		683828 1433B_HUMAN (1-242): 9.01e-140: 393: 87.60		FBW1A_HUMAN (1-605): 0: 551: 100.00
+	Hs
		905276 1433G_HUMAN (1-240): 2.37e-108: 314: 74.59		FBW1A_HUMAN (1-605): 0: 551: 100.00
+	Hs
		927638 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		FBW1B_HUMAN (96-605): 1.89e-143: 428: 85.69
+	Hs
		910139 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		FBW1B_HUMAN (96-605): 1.89e-143: 428: 85.69
+	Hs
		683802 1433B_HUMAN (1-242): 9.01e-140: 393: 87.60		FBW1B_HUMAN (96-605): 1.89e-143: 428: 85.69
+	Hs
		905238 1433G_HUMAN (1-240): 2.37e-108: 314: 74.59		FBW1B_HUMAN (96-605): 1.89e-143: 428: 85.69
+	Hs
		927381 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		FBXW7_HUMAN (76-527): 7.38e-83: 276: 23.71
+	Hs
		909885 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		FBXW7_HUMAN (76-527): 7.38e-83: 276: 23.71
+	Hs
		647171 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		FBXW7_HUMAN (76-527): 7.38e-83: 276: 23.71
+	Hs
		683605 1433B_HUMAN (1-242): 9.01e-140: 393: 87.60		FBXW7_HUMAN (76-527): 7.38e-83: 276: 23.71
+	Hs
		792963 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		LIS1_HUMAN (174-494): 8.99e-74: 243: 21.37
+	Hs
		792954 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		LIS1_HUMAN (174-494): 8.99e-74: 243: 21.37
+	Hs
		683188 1433B_HUMAN (1-242): 9.01e-140: 393: 87.60		LIS1_HUMAN (174-494): 8.99e-74: 243: 21.37
+	Hs
		904953 1433G_HUMAN (1-240): 2.37e-108: 314: 74.59		FBXW7_HUMAN (76-527): 7.38e-83: 276: 23.71
+	Hs
		792950 1433G_HUMAN (1-240): 2.37e-108: 314: 74.59		LIS1_HUMAN (174-494): 8.99e-74: 243: 21.37
+	Hs
		792974 1433F_HUMAN (2-240): 1.26e-107: 312: 74.49		LIS1_HUMAN (174-494): 8.99e-74: 243: 21.37
+	Hs
		903106 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		WDR5_HUMAN (458-605): 5.01e-38: 145: 25.33
+	Mm
		935611 1433F_MOUSE (2-240): 1.16e-107: 312: 74.07		PLRG1_MOUSE (417-604): 1.53e-38: 150: 23.47