HitPredict

Interactor 1: 1433Z (P63104)
14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)
Gene: YWHAZ

Interactor 2: RPGF2 (Q9Y4G8)
Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (CNrasGEF) (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF-1) (Ras/Rap1-associating GEF-1)
Gene: RAPGEF2

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	35271311, 15161933
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Hs			1 1499
+	Hs
		910200 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		RPGF2_HUMAN (1-1499): 0: 1710: 100.00
+	Hs
		647416 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		RPGF2_HUMAN (1-1499): 0: 1710: 100.00
+	Hs
		683851 1433B_HUMAN (1-242): 9.01e-140: 393: 87.60		RPGF2_HUMAN (1-1499): 0: 1710: 100.00
+	Mm
		926845 1433Z_MOUSE (1-245): 3.48e-145: 407: 99.59		RPGF2_MOUSE (1-1499): 0: 1644: 94.67
+	Hs
		927336 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		RPGF6_HUMAN (20-1499): 0: 1352: 63.43
+	Hs
		909851 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		RPGF6_HUMAN (20-1499): 0: 1352: 63.43
+	Hs
		647134 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		RPGF6_HUMAN (20-1499): 0: 1352: 63.43
+	Hs
		683569 1433B_HUMAN (1-242): 9.01e-140: 393: 87.60		RPGF6_HUMAN (20-1499): 0: 1352: 63.43
+	Hs
		683335 1433B_HUMAN (1-242): 9.01e-140: 393: 87.60		RGRF1_HUMAN (277-952): 2.25e-132: 444: 18.05
+	Hs
		647081 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		GRP3_HUMAN (601-1243): 6.86e-137: 440: 14.43
+	Hs
		171544 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		RGL2_HUMAN (559-1220): 8.04e-123: 404: 14.37
+	Hs
		171537 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		RGL2_HUMAN (559-1220): 8.04e-123: 404: 14.37
+	Hs
		171538 1433B_HUMAN (1-242): 9.01e-140: 393: 87.60		RGL2_HUMAN (559-1220): 8.04e-123: 404: 14.37
+	Hs
		171542 1433G_HUMAN (1-240): 2.37e-108: 314: 74.59		RGL2_HUMAN (559-1220): 8.04e-123: 404: 14.37
+	Hs
		927257 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		RGPS2_HUMAN (700-1105): 3.12e-81: 281: 19.76
+	Hs
		909770 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		RGPS2_HUMAN (700-1105): 3.12e-81: 281: 19.76
+	Hs
		647073 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		RGPS2_HUMAN (700-1105): 3.12e-81: 281: 19.76
+	Hs
		683515 1433B_HUMAN (1-242): 9.01e-140: 393: 87.60		RGPS2_HUMAN (700-1105): 3.12e-81: 281: 19.76
+	Hs
		904810 1433G_HUMAN (1-240): 2.37e-108: 314: 74.59		RGPS2_HUMAN (700-1105): 3.12e-81: 281: 19.76
+	Mm
		926773 1433Z_MOUSE (1-245): 3.48e-145: 407: 99.59		RGRF2_MOUSE (277-426): 2.6e-21: 103: 20.00