HitPredict

Interactor 1: 1433Z (P63104)
14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)
Gene: YWHAZ

Interactor 2: IRS2 (Q9Y4H2)
Insulin receptor substrate 2 (IRS-2)
Gene: IRS2

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.86	0.60	0.718

Property	Details
Experiments	26496610, 33961781, 36931259, 28514442, 15161933
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0007165 - signal transduction GO:0019904 - protein domain specific binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Hs			1 1338
+	Hs
		910201 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		IRS2_HUMAN (1-1338): 1.35e-161: 522: 100.00
+	Hs
		724528 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		IRS1_HUMAN (21-1195): 9.72e-82: 296: 32.47
+	Hs
		724526 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		IRS1_HUMAN (21-1195): 9.72e-82: 296: 32.47
+	Hs
		646680 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		IRS1_HUMAN (21-1195): 9.72e-82: 296: 32.47
+	Mm
		724581 1433E_MOUSE (2-241): 9.9e-144: 403: 68.18		IRS1_MOUSE (21-1164): 5.96e-79: 287: 32.74
+	Hs
		151765 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		IRS4_HUMAN (26-1066): 1.14e-74: 274: 21.72
+	Hs
		151760 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		IRS4_HUMAN (26-1066): 1.14e-74: 274: 21.72
+	Dm
		664678 1433Z_DROME (1-245): 3.35e-143: 402: 81.22		IRS1_DROME (27-983): 1.28e-75: 274: 17.98
+	Dm
		955052 1433E_DROME (2-242): 3.33e-143: 402: 66.67		IRS1_DROME (27-983): 1.28e-75: 274: 17.98
+	Hs
		151714 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		IRS4_HUMAN (26-1066): 1.14e-74: 274: 21.72
+	Hs
		297824 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		K0754_HUMAN (846-1326): 4.64e-29: 129: 11.90
+	Hs
		297821 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		K0754_HUMAN (846-1326): 4.64e-29: 129: 11.90
+	Hs
		927045 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		MDC1_HUMAN (414-1332): 5.89e-20: 99.2: 9.03
+	Hs
		927220 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		TICRR_HUMAN (453-1197): 1.42e-14: 81.4: 13.74
+	Hs
		909737 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		TICRR_HUMAN (453-1197): 1.42e-14: 81.4: 13.74
+	Hs
		927196 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		OTOG_HUMAN (965-1323): 2.73e-11: 70.7: 11.75
+	Hs
		909712 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		OTOG_HUMAN (965-1323): 2.73e-11: 70.7: 11.75
+	Hs
		927605 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		DAPLE_HUMAN (303-786): 4.42e-09: 63.4: 12.02
+	Hs
		910111 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		DAPLE_HUMAN (303-786): 4.42e-09: 63.4: 12.02
+	Hs
		647025 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		OTOG_HUMAN (965-1323): 2.73e-11: 70.7: 11.75