HitPredict

Interactor 1: UBE2B (P63146)
Ubiquitin-conjugating enzyme E2 B (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme B) (RAD6 homolog B) (HR6B) (hHR6B) (Ubiquitin carrier protein B) (Ubiquitin-conjugating enzyme E2-17 kDa) (Ubiquitin-protein ligase B)
Gene: UBE2B

Interactor 2: TRI45 (Q9H8W5)
E3 ubiquitin-protein ligase TRIM45 (EC 2.3.2.27) (RING finger protein 99)
Gene: TRIM45

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	24681954
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	UQ_con~zf-RING_UBOX
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process GO:0070936 - protein K48-linked ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 152 Hs			1 580
+	Hs
		1333889 UB2D4_HUMAN (4-150): 5.77e-80: 234: 38.78		TRI45_HUMAN (1-580): 2.41e-161: 474: 100.00
+	Hs
		175730 UB2D4_HUMAN (4-150): 5.77e-80: 234: 38.78		TRI18_HUMAN (20-550): 8.3e-91: 295: 16.61
+	Hs
		175664 UB2D2_HUMAN (4-150): 8.47e-79: 231: 36.74		TRI18_HUMAN (20-550): 8.3e-91: 295: 16.61
+	Hs
		1318738 UB2D4_HUMAN (4-150): 5.77e-80: 234: 38.78		TRIM2_HUMAN (25-505): 1.86e-85: 283: 21.89
+	Hs
		1336390 UB2D4_HUMAN (4-150): 5.77e-80: 234: 38.78		TRI39_HUMAN (132-519): 9.09e-86: 277: 15.45
+	Hs
		1151762 UB2D4_HUMAN (4-150): 5.77e-80: 234: 38.78		Q6GX22_HUMAN (20-550): 1.16e-83: 276: 16.23
+	Mm
		895980 UB2D1_MOUSE (4-150): 6.1e-79: 231: 38.10		LIN41_MOUSE (40-524): 2.2e-82: 277: 22.34
+	Hs
		1356055 UB2D4_HUMAN (4-150): 5.77e-80: 234: 38.78		TRIM1_HUMAN (9-550): 6.28e-82: 273: 15.82
+	Hs
		262201 UB2D4_HUMAN (4-150): 5.77e-80: 234: 38.78		TRIM3_HUMAN (16-505): 1.13e-76: 259: 21.94
+	Hs
		262167 UB2D2_HUMAN (4-150): 8.47e-79: 231: 36.74		TRIM3_HUMAN (16-505): 1.13e-76: 259: 21.94
+	Hs
		537142 UB2D4_HUMAN (4-150): 5.77e-80: 234: 38.78		TRI27_HUMAN (130-570): 4.55e-76: 252: 16.06
+	Mm
		919925 UB2D2_MOUSE (4-150): 8.47e-79: 231: 36.74		TRI17_MOUSE (123-520): 6.27e-77: 253: 14.81
+	Hs
		536779 UB2D2_HUMAN (4-150): 8.47e-79: 231: 36.74		TRI27_HUMAN (130-570): 4.55e-76: 252: 16.06
+	Hs
		135045 UB2D4_HUMAN (4-150): 5.77e-80: 234: 38.78		TRI38_HUMAN (125-521): 7.67e-74: 244: 13.52
+	Hs
		1318719 UB2D4_HUMAN (4-150): 5.77e-80: 234: 38.78		TRIM5_HUMAN (131-518): 1.26e-72: 242: 15.96
+	Hs
		135019 UB2D2_HUMAN (4-150): 8.47e-79: 231: 36.74		TRI38_HUMAN (125-521): 7.67e-74: 244: 13.52
+	Hs
		1377469 UB2D4_HUMAN (4-150): 5.77e-80: 234: 38.78		TRI17_HUMAN (123-520): 3.71e-68: 230: 15.26
+	Hs
		1285831 UB2D4_HUMAN (4-150): 5.77e-80: 234: 38.78		TRI43_HUMAN (121-518): 1.23e-67: 227: 12.56
+	Hs
		734819 UB2D4_HUMAN (4-150): 5.77e-80: 234: 38.78		TRI23_HUMAN (4-398): 3.46e-58: 205: 17.12
+	Hs
		1317493 UB2D4_HUMAN (4-150): 5.77e-80: 234: 38.78		TRI54_HUMAN (6-371): 1.13e-57: 198: 16.03