HitPredict

Interactor 1: UBE2B (P63146)
Ubiquitin-conjugating enzyme E2 B (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme B) (RAD6 homolog B) (HR6B) (hHR6B) (Ubiquitin carrier protein B) (Ubiquitin-conjugating enzyme E2-17 kDa) (Ubiquitin-protein ligase B)
Gene: UBE2B

Interactor 2: HERC5 (Q9UII4)
E3 ISG15--protein ligase HERC5 (EC 2.3.2.-) (Cyclin-E-binding protein 1) (HECT domain and RCC1-like domain-containing protein 5)
Gene: HERC5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35671810
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HECT~UQ_con
Common GO terms	GO:0000209 - protein polyubiquitination GO:0004842 - ubiquitin-protein transferase activity GO:0005737 - cytoplasm GO:0006511 - ubiquitin-dependent protein catabolic process GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 152 Hs			1 1024
+	Hs
		919895 UB2D2_HUMAN (4-150): 8.47e-79: 231: 36.74		HERC5_HUMAN (1-1024): 0: 1123: 100.00
+	Hs
		849311 UB2D1_HUMAN (4-150): 6.1e-79: 231: 38.10		UBE3A_HUMAN (414-1024): 1.12e-172: 529: 25.37
+	Hs
		919710 UB2D2_HUMAN (4-150): 8.47e-79: 231: 36.74		UBE3A_HUMAN (414-1024): 1.12e-172: 529: 25.37
+	Hs
		919860 UB2D2_HUMAN (4-150): 8.47e-79: 231: 36.74		WWP1_HUMAN (588-1024): 8.35e-169: 520: 21.93
+	Hs
		125808 UB2D4_HUMAN (4-150): 5.77e-80: 234: 38.78		WWP2_HUMAN (599-1024): 1.14e-167: 516: 22.02
+	Hs
		125262 UB2D1_HUMAN (4-150): 6.1e-79: 231: 38.10		WWP2_HUMAN (599-1024): 1.14e-167: 516: 22.02
+	Hs
		125335 UB2D2_HUMAN (4-150): 8.47e-79: 231: 36.74		WWP2_HUMAN (599-1024): 1.14e-167: 516: 22.02
+	Hs
		1294888 UB2D4_HUMAN (4-150): 5.77e-80: 234: 38.78		ITCH_HUMAN (593-1024): 1.76e-165: 511: 24.22
+	Hs
		808052 UB2D1_HUMAN (4-150): 6.1e-79: 231: 38.10		NEDD4_HUMAN (652-1023): 3.7e-161: 511: 26.04
+	Hs
		808078 UB2D2_HUMAN (4-150): 8.47e-79: 231: 36.74		NEDD4_HUMAN (652-1023): 3.7e-161: 511: 26.04
+	Hs
		849411 UB2D1_HUMAN (4-150): 6.1e-79: 231: 38.10		ITCH_HUMAN (593-1024): 1.76e-165: 511: 24.22
+	Hs
		919827 UB2D2_HUMAN (4-150): 8.47e-79: 231: 36.74		ITCH_HUMAN (593-1024): 1.76e-165: 511: 24.22
+	Hs
		919834 UB2D2_HUMAN (4-150): 8.47e-79: 231: 36.74		NED4L_HUMAN (652-1023): 2.49e-164: 510: 28.13
+	Hs
		849351 UB2D1_HUMAN (4-150): 6.1e-79: 231: 38.10		HECW1_HUMAN (532-1024): 4.53e-156: 504: 22.94
+	Hs
		919762 UB2D2_HUMAN (4-150): 8.47e-79: 231: 36.74		HECW1_HUMAN (532-1024): 4.53e-156: 504: 22.94
+	Hs
		919889 UB2D2_HUMAN (4-150): 8.47e-79: 231: 36.74		HECW2_HUMAN (534-1024): 2.54e-153: 496: 23.43
+	Hs
		919867 UB2D2_HUMAN (4-150): 8.47e-79: 231: 36.74		SMUF2_HUMAN (648-1024): 5.74e-160: 491: 26.22
+	Hs
		919869 UB2D2_HUMAN (4-150): 8.47e-79: 231: 36.74		SMUF1_HUMAN (593-1024): 1.71e-157: 485: 23.71
+	Hs
		919741 UB2D2_HUMAN (4-150): 8.47e-79: 231: 36.74		HERC4_HUMAN (317-431): 2.55e-13: 76.6: 11.02
+	Hs
		849333 UB2D1_HUMAN (4-150): 6.1e-79: 231: 38.10		HERC3_HUMAN (317-460): 3.68e-11: 69.7: 10.88