HitPredict

Interactor 1: RSMN (P63162)
Small nuclear ribonucleoprotein-associated protein N (snRNP-N) (Sm protein D) (Sm-D) (Sm protein N) (Sm-N) (SmN) (Tissue-specific-splicing protein)
Gene: SNRPN

Interactor 2: U5S1 (Q15029)
116 kDa U5 small nuclear ribonucleoprotein component (Elongation factor Tu GTP-binding domain-containing protein 2) (SNU114 homolog) (hSNU114) (U5 snRNP-specific protein, 116 kDa) (U5-116 kDa)
Gene: EFTUD2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	28515276, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	GTP_EFTU~LSM
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0046540 - U4/U6 x U5 tri-snRNP complex GO:0071013 - catalytic step 2 spliceosome
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 240 Hs			1 972
+	Hs
		538964 RSMB_HUMAN (1-168): 1.09e-43: 148: 96.43		U5S1_HUMAN (1-972): 0: 1062: 100.00
+	Hs
		123946 SPT5H_HUMAN (100-228): 4.97e-25: 105: 17.69		U5S1_HUMAN (1-972): 0: 1062: 100.00
+	Sp
		292950 RSMB_SCHPO (6-156): 1.85e-18: 80.8: 44.74		SN114_SCHPO (1-970): 0: 928: 54.22
+	Sc
		731728 RSMB_YEAST (1-165): 2.64e-36: 128: 28.72		SN114_YEAST (3-967): 0: 692: 32.82