HitPredict

Interactor 1: RSMN (P63162)
Small nuclear ribonucleoprotein-associated protein N (snRNP-N) (Sm protein D) (Sm-D) (Sm protein N) (Sm-N) (SmN) (Tissue-specific-splicing protein)
Gene: SNRPN

Interactor 2: LSM2 (Q9Y333)
U6 snRNA-associated Sm-like protein LSm2 (Protein G7b) (Small nuclear ribonuclear protein D homolog) (snRNP core Sm-like protein Sm-x5)
Gene: LSM2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	LSM~LSM
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0046540 - U4/U6 x U5 tri-snRNP complex and 1 others more... GO:0071013 - catalytic step 2 spliceosome
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 240 Hs			1 95
+	Hs
		539197 RSMB_HUMAN (1-168): 1.09e-43: 148: 96.43		LSM2_HUMAN (1-95): 4.21e-38: 124: 100.00
+	Hs
		539204 RSMB_HUMAN (1-168): 1.09e-43: 148: 96.43		LSM4_HUMAN (1-87): 3.25e-32: 110: 32.58
+	Hs
		538894 RSMB_HUMAN (1-168): 1.09e-43: 148: 96.43		SMD1_HUMAN (1-95): 6.66e-29: 101: 28.42
+	Hs
		928049 RSMN_HUMAN (1-212): 4.46e-39: 137: 100.00		LSM4_HUMAN (1-87): 3.25e-32: 110: 32.58
+	Hs
		912265 RSMN_HUMAN (1-212): 4.46e-39: 137: 100.00		SMD1_HUMAN (1-95): 6.66e-29: 101: 28.42
+	Hs
		538896 RSMB_HUMAN (1-168): 1.09e-43: 148: 96.43		SMD3_HUMAN (2-88): 6.44e-24: 89.6: 20.69
+	Hs
		538890 RSMB_HUMAN (1-168): 1.09e-43: 148: 96.43		RUXF_HUMAN (3-71): 2.45e-23: 86.9: 31.43
+	Sc
		746294 RSMB_YEAST (1-165): 2.64e-36: 128: 28.72		LSM2_YEAST (1-95): 2.94e-31: 106: 63.16
+	Hs
		912611 RSMN_HUMAN (1-212): 4.46e-39: 137: 100.00		SMD3_HUMAN (2-88): 6.44e-24: 89.6: 20.69
+	Hs
		911801 RSMN_HUMAN (1-212): 4.46e-39: 137: 100.00		RUXF_HUMAN (3-71): 2.45e-23: 86.9: 31.43
+	At
		1323437 Q9FI15_ARATH (1-206): 2.87e-29: 112: 47.71		SMD1B_ARATH (1-93): 3.01e-29: 102: 26.88
+	Sc
		766909 RSMB_YEAST (1-165): 2.64e-36: 128: 28.72		LSM4_YEAST (1-83): 6.73e-22: 85.7: 22.83
+	Sc
		766915 RSMB_YEAST (1-165): 2.64e-36: 128: 28.72		SMD3_YEAST (2-91): 3.42e-22: 84.2: 18.89
+	At
		1352883 Q9SUN5_ARATH (1-206): 3.66e-28: 109: 48.56		SMD1B_ARATH (1-93): 3.01e-29: 102: 26.88
+	Hs
		123900 SPT5H_HUMAN (100-228): 4.97e-25: 105: 17.69		SMD1_HUMAN (1-95): 6.66e-29: 101: 28.42
+	Dm
		218359 RSMB_DROME (1-204): 1.07e-29: 111: 58.82		SMD3_DROME (2-74): 2.73e-23: 88.4: 23.29
+	Hs
		123899 SPT5H_HUMAN (100-228): 4.97e-25: 105: 17.69		RUXF_HUMAN (3-71): 2.45e-23: 86.9: 31.43