HitPredict

Interactor 1: RSMN (P63162)
Small nuclear ribonucleoprotein-associated protein N (snRNP-N) (Sm protein D) (Sm-D) (Sm protein N) (Sm-N) (SmN) (Tissue-specific-splicing protein)
Gene: SNRPN

Interactor 2: LSM5 (Q9Y4Y9)
U6 snRNA-associated Sm-like protein LSm5
Gene: LSM5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	LSM~LSM
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0046540 - U4/U6 x U5 tri-snRNP complex
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 240 Hs			1 91
+	Hs
		539203 RSMB_HUMAN (1-168): 1.09e-43: 148: 96.43		LSM5_HUMAN (1-91): 1.1e-36: 120: 100.00
+	Hs
		538889 RSMB_HUMAN (1-168): 1.09e-43: 148: 96.43		RUXE_HUMAN (1-84): 8.29e-27: 95.4: 26.37
+	Hs
		538892 RSMB_HUMAN (1-168): 1.09e-43: 148: 96.43		LSM3_HUMAN (14-85): 5.98e-23: 86.1: 26.83
+	Hs
		911614 RSMN_HUMAN (1-212): 4.46e-39: 137: 100.00		RUXE_HUMAN (1-84): 8.29e-27: 95.4: 26.37
+	Hs
		539178 RSMB_HUMAN (1-168): 1.09e-43: 148: 96.43		LSM7_HUMAN (7-91): 7.4e-18: 73: 21.11
+	Sc
		766910 RSMB_YEAST (1-165): 2.64e-36: 128: 28.72		LSM5_YEAST (11-87): 9.08e-24: 88: 47.56
+	Sc
		766937 RSMB_YEAST (1-165): 2.64e-36: 128: 28.72		LSM3_YEAST (14-90): 1.46e-22: 84.6: 23.46
+	Sc
		766977 RSMB_YEAST (1-165): 2.64e-36: 128: 28.72		RUXE_YEAST (14-86): 1.66e-21: 82.3: 24.39
+	Hs
		538891 RSMB_HUMAN (1-168): 1.09e-43: 148: 96.43		RUXG_HUMAN (10-82): 1.17e-12: 59.2: 26.03
+	Hs
		68400 RSMB_HUMAN (1-168): 1.09e-43: 148: 96.43		RUXGL_HUMAN (10-82): 2.1e-11: 56.1: 26.03
+	Hs
		912026 RSMN_HUMAN (1-212): 4.46e-39: 137: 100.00		RUXG_HUMAN (10-82): 1.17e-12: 59.2: 26.03
+	Hs
		68412 RSMN_HUMAN (1-212): 4.46e-39: 137: 100.00		RUXGL_HUMAN (10-82): 2.1e-11: 56.1: 26.03
+	Sc
		766934 RSMB_YEAST (1-165): 2.64e-36: 128: 28.72		LSM7_YEAST (9-89): 7.29e-14: 63.4: 24.72
+	Dm
		984916 Q8IPZ7_DROME (8-94): 7.25e-26: 99.3: 26.44		RSMB_DROME (22-83): 3.18e-11: 58: 30.44