HitPredict

Interactor 1: SUMO1 (P63165)
Small ubiquitin-related modifier 1 (SUMO-1) (GAP-modifying protein 1) (GMP1) (SMT3 homolog 3) (Sentrin) (Ubiquitin-homology domain protein PIC1) (Ubiquitin-like protein SMT3C) (Smt3C) (Ubiquitin-like protein UBL1)
Gene: SUMO1

Interactor 2: Q7KZS0 (Q7KZS0)
SUMO-conjugating enzyme UBC9 (RING-type E3 SUMO transferase UBC9) (SUMO-protein ligase) (Ubiquitin carrier protein 9) (Ubiquitin carrier protein I) (Ubiquitin-conjugating enzyme E2 I) (Ubiquitin-protein ligase I)
Gene: UBE2I

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	25416956, unassigned1304
Identification Methods	validated two hybrid, two hybrid prey pooling approach, two hybrid array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Rad60-SLD~UQ_con
Common GO terms	GO:0005634 - nucleus GO:0016925 - protein sumoylation
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 101 Hs			1 184
+	Hs
		102167 SUMO5_HUMAN (1-101): 4.52e-41: 132: 88.12		Q7KZS0_HUMAN (1-184): 1.19e-72: 218: 100.00
+	Hs
		928056 SUMO1_HUMAN (1-101): 1.01e-41: 134: 100.00		UBC9_HUMAN (1-158): 1.17e-69: 210: 86.71
+	Mm
		928242 SUMO1_MOUSE (1-101): 1.01e-41: 134: 100.00		UBC9_MOUSE (1-158): 1.17e-69: 210: 86.71
+	Hs
		102156 SUMO5_HUMAN (1-101): 4.52e-41: 132: 88.12		UBC9_HUMAN (1-158): 1.17e-69: 210: 86.71
+	Mm
		930505 SUMO3_MOUSE (1-100): 3.1e-40: 130: 46.00		UBC9_MOUSE (1-158): 1.17e-69: 210: 86.71
+	Rn
		930510 SUMO3_RAT (1-100): 1.5e-39: 128: 46.00		UBC9_RAT (1-158): 1.17e-69: 210: 86.71
+	Hs
		902509 SUMO2_HUMAN (1-97): 1.77e-38: 125: 45.36		UBC9_HUMAN (1-158): 1.17e-69: 210: 86.71
+	Hs
		879101 SUMO3_HUMAN (1-97): 1.65e-37: 123: 47.42		UBC9_HUMAN (1-158): 1.17e-69: 210: 86.71
+	At
		1114967 SUMO2_ARATH (6-99): 5.11e-38: 124: 45.75		SCE1_ARATH (2-137): 8.32e-65: 198: 67.65
+	At
		1114966 SUMO3_ARATH (6-97): 1.88e-37: 123: 38.04		SCE1_ARATH (2-137): 8.32e-65: 198: 67.65
+	Sp
		140897 PMT3_SCHPO (2-99): 1.41e-36: 121: 51.02		UBC9_SCHPO (1-137): 1.6e-65: 199: 66.42
+	Dm
		332535 O97102_DROME (11-98): 1.01e-36: 120: 51.14		Q7KNM2_DROME (1-158): 9.6e-65: 197: 75.95
+	Ce
		879079 SUMO_CAEEL (9-97): 4.4e-34: 114: 58.43		UBC9_CAEEL (1-137): 7.13e-67: 203: 78.10
+	At
		878960 SUMO1_ARATH (9-95): 3e-35: 117: 47.13		SCE1_ARATH (2-137): 8.32e-65: 198: 67.65
+	Zm
		74333 B6TQW3_MAIZE (3-95): 8.18e-24: 92.1: 27.96		B4FC97_MAIZE (4-157): 2.68e-74: 221: 32.47
+	Mm
		140343 NF2IP_MOUSE (10-90): 1.79e-23: 94: 24.39		UBC9_MOUSE (1-158): 1.17e-69: 210: 86.71
+	At
		1114930 Q8LCF9_ARATH (2-95): 5.94e-24: 92.1: 26.60		SCE1_ARATH (2-137): 8.32e-65: 198: 67.65
+	Sc
		841454 SMT3_YEAST (3-99): 7.04e-32: 109: 47.42		UBC9_YEAST (1-134): 1.03e-53: 169: 59.70