HitPredict

Interactor 1: DYL1 (P63167)
Dynein light chain 1, cytoplasmic (8 kDa dynein light chain) (DLC8) (Dynein light chain LC8-type 1) (Protein inhibitor of neuronal nitric oxide synthase) (PIN)
Gene: DYNLL1

Interactor 2: NEK6 (Q9HC98)
Serine/threonine-protein kinase Nek6 (EC 2.7.11.34) (Never in mitosis A-related kinase 6) (NimA-related protein kinase 6) (Protein kinase SID6-1512)
Gene: NEK6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.621

Property	Details
Experiments	17353931, 32707033
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005874 - microtubule GO:0006915 - apoptotic process
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 89 Hs			1 313
+	Hs
		928409 DYL1_HUMAN (1-89): 1.96e-46: 145: 100.00		NEK7_HUMAN (22-313): 4.39e-143: 407: 81.16
+	Hs
		568621 DYL1_HUMAN (1-89): 1.96e-46: 145: 100.00		KAPCA_HUMAN (10-313): 3.78e-125: 363: 24.01
+	Hs
		610709 DYL1_HUMAN (1-89): 1.96e-46: 145: 100.00		KAPCB_HUMAN (10-313): 1.19e-124: 361: 24.01
+	Hs
		568762 DYL2_HUMAN (1-89): 1.68e-45: 142: 93.26		KAPCA_HUMAN (10-313): 3.78e-125: 363: 24.01
+	Hs
		609658 DYL1_HUMAN (1-89): 1.96e-46: 145: 100.00		KAPCG_HUMAN (31-313): 1.46e-123: 359: 25.44
+	Hs
		610764 DYL2_HUMAN (1-89): 1.68e-45: 142: 93.26		KAPCB_HUMAN (10-313): 1.19e-124: 361: 24.01
+	Hs
		609686 DYL2_HUMAN (1-89): 1.68e-45: 142: 93.26		KAPCG_HUMAN (31-313): 1.46e-123: 359: 25.44
+	Hs
		160496 DYL1_HUMAN (1-89): 1.96e-46: 145: 100.00		AURKA_HUMAN (5-312): 3e-109: 324: 25.00
+	Hs
		1291277 DYL2_HUMAN (1-89): 1.68e-45: 142: 93.26		NEK1_HUMAN (49-311): 1.78e-52: 187: 36.84
+	Hs
		928405 DYL1_HUMAN (1-89): 1.96e-46: 145: 100.00		NEK9_HUMAN (51-294): 5.71e-47: 171: 39.68
+	Hs
		1254363 DYL2_HUMAN (1-89): 1.68e-45: 142: 93.26		NEK9_HUMAN (51-294): 5.71e-47: 171: 39.68
+	Hs
		101710 F8VXI7_HUMAN (1-42): 4.82e-14: 61.9: 100.00		NEK10_HUMAN (42-296): 3.61e-47: 171: 34.85