HitPredict

Interactor 1: SKP1 (P63208)
S-phase kinase-associated protein 1 (Cyclin-A/CDK2-associated protein p19) (p19A) (Organ of Corti protein 2) (OCP-2) (Organ of Corti protein II) (OCP-II) (RNA polymerase II elongation factor-like protein) (SIII) (Transcription elongation factor B polypeptide 1-like) (p19skp1)
Gene: SKP1

Interactor 2: RING1 (Q06587)
E3 ubiquitin-protein ligase RING1 (EC 2.3.2.27) (Polycomb complex protein RING1) (RING finger protein 1) (RING-type E3 ubiquitin transferase RING1) (Really interesting new gene 1 protein)
Gene: RING1

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.675

Property	Details
Experiments	27705803, 24981860, 33961781
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0006338 - chromatin remodeling GO:0016567 - protein ubiquitination and 1 others more... GO:0031519 - PcG protein complex
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 163 Hs			1 406
+	Mm
		1321746 SKP1_MOUSE (1-163): 8.88e-88: 255: 99.39		RING2_MOUSE (8-406): 2.94e-100: 303: 54.25
+	Hs
		929043 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		RING2_HUMAN (8-406): 4.9e-100: 302: 54.25
+	Hs
		717667 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		BMI1_HUMAN (31-378): 4.06e-63: 207: 14.16
+	Hs
		584925 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		RO52_HUMAN (33-392): 4.67e-43: 158: 13.14
+	Hs
		718386 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		PCGF2_HUMAN (31-377): 1.44e-41: 151: 14.37
+	Hs
		928999 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		COP1_HUMAN (40-326): 3.5e-39: 151: 18.31
+	Hs
		929051 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		PCGF6_HUMAN (31-157): 1.02e-40: 149: 23.08
+	Hs
		929047 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		PCGF1_HUMAN (25-133): 3.54e-40: 145: 25.00
+	Hs
		928932 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		PCGF3_HUMAN (34-224): 6.2e-39: 141: 17.53
+	Hs
		749352 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		BRCA1_HUMAN (33-361): 4.24e-35: 139: 15.63
+	Hs
		928968 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		PCGF5_HUMAN (31-147): 4.96e-38: 139: 23.33
+	Dm
		285038 O77430_DROME (1-163): 1.01e-79: 235: 76.69		Q9VV77_DROME (33-129): 1.77e-37: 137: 27.00