HitPredict

Interactor 1: SKP1 (P63208)
S-phase kinase-associated protein 1 (Cyclin-A/CDK2-associated protein p19) (p19A) (Organ of Corti protein 2) (OCP-2) (Organ of Corti protein II) (OCP-II) (RNA polymerase II elongation factor-like protein) (SIII) (Transcription elongation factor B polypeptide 1-like) (p19skp1)
Gene: SKP1

Interactor 2: CUL1 (Q13616)
Cullin-1 (CUL-1)
Gene: CUL1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.99 1.00 0.997

The method score is based on:

Property Details
Experiments 23770852, 26540345, 26474281, 26976582, 27705803, 29863914, 12628165, 9430629, 33961781, 34499862, 16357137, 15452136, 19270694, 10023660, 12684064, 9663463, 9636170, 11027288, 12504025, 23324393 and 38 others

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Identification Methods affinity chromatography technology, pull down, x-ray crystallography, two hybrid, anti tag coimmunoprecipitation, isothermal titration calorimetry, tandem affinity purification, anti bait coimmunoprecipitation, coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Cullin~Skp1_POZ
Common GO terms GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006513 - protein monoubiquitination
and 6 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 163
Hs

1 776
+ Mm
+ Hs
+ Hs
+ Dm
+ Ce
+ Hs
+ Dm
+ Dm
+ Ce
+ Hs
+ Ce
+ Sp
+ At
+ At
+ At
+ At
+ At
+ At
+ Hs
+ Ce

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024