HitPredict

Interactor 1: SKP1 (P63208)
S-phase kinase-associated protein 1 (Cyclin-A/CDK2-associated protein p19) (p19A) (Organ of Corti protein 2) (OCP-2) (Organ of Corti protein II) (OCP-II) (RNA polymerase II elongation factor-like protein) (SIII) (Transcription elongation factor B polypeptide 1-like) (p19skp1)
Gene: SKP1

Interactor 2: FBX16 (Q8IX29)
F-box only protein 16
Gene: FBXO16

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.80	0.757

Property	Details
Experiments	30596474, 30714168, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	F-box-like~Skp1
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 163 Hs			1 292
+	Hs
		928876 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		ECT2L_HUMAN (14-221): 3.97e-68: 229: 38.89
+	Xl
		1174984 SKP1_XENLA (1-163): 1.62e-87: 254: 100.00		TRCB_XENLA (6-238): 3.23e-61: 203: 17.98
+	Mm
		1112932 SKP1_MOUSE (1-163): 8.88e-88: 255: 99.39		FBW1A_MOUSE (9-238): 1.2e-59: 201: 16.86
+	Hs
		929125 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		FBW1A_HUMAN (9-238): 5.85e-60: 202: 17.24
+	Mm
		1131317 SKP1_MOUSE (1-163): 8.88e-88: 255: 99.39		FBW1B_MOUSE (1-234): 1.32e-56: 192: 16.29
+	Hs
		929110 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		FBW1B_HUMAN (1-234): 1.94e-56: 191: 16.29
+	Dm
		218244 O77430_DROME (1-163): 1.01e-79: 235: 76.69		O44382_DROME (8-236): 2.13e-50: 175: 15.56
+	Dm
		285012 O77430_DROME (1-163): 1.01e-79: 235: 76.69		Q9VDE3_DROME (8-236): 1.34e-50: 175: 15.56
+	Mm
		1351515 SKP1_MOUSE (1-163): 8.88e-88: 255: 99.39		Q9QUH1_MOUSE (30-179): 6.48e-42: 151: 23.18
+	Hs
		929116 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		FBXW2_HUMAN (30-179): 7.98e-42: 151: 23.18
+	Mm
		1257397 SKP1_MOUSE (1-163): 8.88e-88: 255: 99.39		FBXW7_MOUSE (4-237): 1.06e-37: 143: 18.60
+	Hs
		929021 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		FBXW7_HUMAN (1-237): 3.19e-38: 144: 18.70
+	Dm
		285042 O77430_DROME (1-163): 1.01e-79: 235: 76.69		FBXW7_DROME (7-231): 7.29e-42: 155: 20.41
+	Hs
		928984 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		FBXW8_HUMAN (88-167): 5.13e-24: 103: 31.25
+	Mm
		1206617 SKP1_MOUSE (1-163): 8.88e-88: 255: 99.39		FBXW8_MOUSE (88-167): 1.33e-22: 99.1: 30.00
+	Hs
		928938 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		FBX48_HUMAN (85-175): 2.63e-18: 81.8: 22.45
+	Hs
		929108 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		FBXL5_HUMAN (89-133): 1.45e-10: 63.7: 42.22
+	Hs
		928958 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		FBW12_HUMAN (92-226): 1.69e-10: 63.3: 21.83
+	Hs
		929107 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		FBX3_HUMAN (89-157): 6.04e-10: 61.4: 31.88
+	Hs
		929075 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		FBX6_HUMAN (87-167): 3.81e-09: 58.3: 28.05