HitPredict

Interactor 1: SKP1 (P63208)
S-phase kinase-associated protein 1 (Cyclin-A/CDK2-associated protein p19) (p19A) (Organ of Corti protein 2) (OCP-2) (Organ of Corti protein II) (OCP-II) (RNA polymerase II elongation factor-like protein) (SIII) (Transcription elongation factor B polypeptide 1-like) (p19skp1)
Gene: SKP1

Interactor 2: FXL14 (Q8N1E6)
F-box/LRR-repeat protein 14 (F-box and leucine-rich repeat protein 14)
Gene: FBXL14

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.86	1.00	0.931

Property	Details
Experiments	27705803, 32296183, 28514442, 33961781, unassigned1304
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation, two hybrid array, validated two hybrid, two hybrid prey pooling approach, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	F-box-like~Skp1
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019005 - SCF ubiquitin ligase complex GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 163 Hs			1 418
+	Mm
		1321913 SKP1_MOUSE (1-163): 8.88e-88: 255: 99.39		FXL20_MOUSE (7-409): 1.29e-64: 215: 27.32
+	Hs
		929033 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		FXL20_HUMAN (7-409): 1.18e-64: 215: 27.56
+	Dm
		285014 O77430_DROME (1-163): 1.01e-79: 235: 76.69		Q9VF10_DROME (6-367): 3.96e-61: 212: 23.84
+	Hs
		928997 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		KDM2B_HUMAN (205-401): 7.04e-32: 130: 20.83
+	Mm
		1158242 SKP1_MOUSE (1-163): 8.88e-88: 255: 99.39		KDM2B_MOUSE (205-401): 6.68e-30: 124: 20.37
+	Hs
		929057 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		FXL15_HUMAN (114-379): 2.98e-31: 122: 24.44
+	Hs
		929099 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		FBXL7_HUMAN (201-417): 8.79e-29: 119: 24.35
+	Hs
		929092 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		FXL17_HUMAN (178-414): 1.46e-22: 102: 18.11
+	Hs
		929109 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		FBXL4_HUMAN (180-391): 3.38e-20: 94.7: 25.89
+	Hs
		929111 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		FBXL2_HUMAN (255-416): 1.88e-20: 94.6: 25.90
+	Dm
		285016 O77430_DROME (1-163): 1.01e-79: 235: 76.69		Q9VFN3_DROME (2-406): 4.18e-25: 109: 19.16
+	Hs
		928952 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		FXL19_HUMAN (176-406): 9.21e-17: 84.3: 20.87
+	Hs
		929126 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		KDM2A_HUMAN (121-386): 1.6e-16: 83.9: 20.68
+	Ce
		105464 SKR1_CAEEL (4-162): 2.25e-78: 232: 70.81		FBXL_CAEEL (92-251): 2.4e-19: 91.5: 28.13
+	Dm
		284984 O77430_DROME (1-163): 1.01e-79: 235: 76.69		Q7K0V7_DROME (48-321): 3.05e-17: 85.9: 16.39
+	Dm
		285018 O77430_DROME (1-163): 1.01e-79: 235: 76.69		JHD1_DROME (211-388): 6.64e-17: 85.1: 24.12
+	Mm
		58200 SKP1_MOUSE (1-163): 8.88e-88: 255: 99.39		FXL16_MOUSE (259-417): 3.85e-09: 60.4: 17.07
+	Hs
		928985 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		FXL16_HUMAN (259-417): 2e-09: 61.2: 17.07
+	Dm
		285046 O77430_DROME (1-163): 1.01e-79: 235: 76.69		Q9W214_DROME (7-261): 3.59e-15: 79.2: 22.88
+	Dm
		1178751 Q7KJ69_DROME (1-163): 1.92e-74: 221: 67.49		Q7K0V7_DROME (48-321): 3.05e-17: 85.9: 16.39