HitPredict

Interactor 1: SKP1 (P63208)
S-phase kinase-associated protein 1 (Cyclin-A/CDK2-associated protein p19) (p19A) (Organ of Corti protein 2) (OCP-2) (Organ of Corti protein II) (OCP-II) (RNA polymerase II elongation factor-like protein) (SIII) (Transcription elongation factor B polypeptide 1-like) (p19skp1)
Gene: SKP1

Interactor 2: FXL16 (Q8N461)
F-box/LRR-repeat protein 16 (F-box and leucine-rich repeat protein 16)
Gene: FBXL16

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	29499133, 32345600, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0019005 - SCF ubiquitin ligase complex GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 163 Hs			1 479
+	Mm
		58200 SKP1_MOUSE (1-163): 8.88e-88: 255: 99.39		FXL16_MOUSE (1-479): 8.4e-85: 270: 96.45
+	Hs
		928983 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		FXL14_HUMAN (286-479): 1.58e-33: 132: 27.94
+	Hs
		929099 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		FBXL7_HUMAN (204-479): 1.4e-31: 128: 23.99
+	Hs
		929109 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		FBXL4_HUMAN (80-418): 5.12e-31: 128: 19.55
+	Dm
		285014 O77430_DROME (1-163): 1.01e-79: 235: 76.69		Q9VF10_DROME (202-479): 5.72e-37: 146: 23.76
+	Mm
		1321913 SKP1_MOUSE (1-163): 8.88e-88: 255: 99.39		FXL20_MOUSE (279-479): 1.57e-27: 116: 26.96
+	Hs
		929033 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		FXL20_HUMAN (279-479): 9.53e-28: 117: 26.47
+	Hs
		929111 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		FBXL2_HUMAN (270-479): 2.2e-27: 115: 25.35
+	Dm
		285046 O77430_DROME (1-163): 1.01e-79: 235: 76.69		Q9W214_DROME (106-380): 3.38e-32: 130: 18.71
+	Hs
		929092 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		FXL17_HUMAN (121-375): 1.84e-24: 108: 15.33
+	Ce
		105464 SKR1_CAEEL (4-162): 2.25e-78: 232: 70.81		FBXL_CAEEL (270-479): 4.42e-31: 126: 21.60
+	Hs
		928997 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		KDM2B_HUMAN (226-472): 5.46e-20: 95.6: 21.27
+	Hs
		929057 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		FXL15_HUMAN (306-478): 1.32e-20: 94: 24.16
+	Hs
		928895 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		SKP2_HUMAN (297-479): 4.57e-18: 88.2: 22.34
+	Hs
		928987 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		FBXL6_HUMAN (283-479): 6.4e-16: 82.1: 20.67
+	Dm
		285016 O77430_DROME (1-163): 1.01e-79: 235: 76.69		Q9VFN3_DROME (156-344): 5.61e-17: 85.6: 17.26
+	Mm
		1376704 SKP1_MOUSE (1-163): 8.88e-88: 255: 99.39		SKP2_MOUSE (347-479): 1.53e-09: 61.7: 18.25
+	Dm
		284984 O77430_DROME (1-163): 1.01e-79: 235: 76.69		Q7K0V7_DROME (138-319): 1.33e-12: 72.1: 20.00
+	Dm
		284989 O77430_DROME (1-163): 1.01e-79: 235: 76.69		Q8IGU5_DROME (185-381): 2.65e-09: 61.3: 15.06
+	Dm
		284994 O77430_DROME (1-163): 1.01e-79: 235: 76.69		Q8T0K1_DROME (185-381): 9.07e-09: 59.7: 15.06