HitPredict

Interactor 1: SKP1 (P63208)
S-phase kinase-associated protein 1 (Cyclin-A/CDK2-associated protein p19) (p19A) (Organ of Corti protein 2) (OCP-2) (Organ of Corti protein II) (OCP-II) (RNA polymerase II elongation factor-like protein) (SIII) (Transcription elongation factor B polypeptide 1-like) (p19skp1)
Gene: SKP1

Interactor 2: FBXW7 (Q969H0)
F-box/WD repeat-containing protein 7 (Archipelago homolog) (hAgo) (F-box and WD-40 domain-containing protein 7) (F-box protein FBX30) (SEL-10) (hCdc4)
Gene: FBXW7

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.993

The method score is based on:

Property Details
Experiments 26540345, 26474281, 26976582, 27247421, 28007894, 12628165, 30728155, 11585921, 17434132, 22524983, 25720964, 26087183, 28614300, 28522751, 29408378, 29346117, 31210753, 32086376, 31285543, 32350066 and 11 others

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Identification Methods affinity chromatography technology, pull down, fluorescent resonance energy transfer, x-ray crystallography, biochemical, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains F-box-like~Skp1
Common GO terms GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0016567 - protein ubiquitination
and 4 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 163
Hs

1 707
+ Mm
+ Dm
+ Sp
+ Sp
+ Hs
+ Sp
+ Sp
+ Mm
+ Hs
+ Ce
+ Hs
+ Mm
+ Xl
+ Hs
+ Mm
+ Hs
+ Dm
+ Dm
+ Dm
+ Ce

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Last updated: 15 Jul 2024