HitPredict

Interactor 1: SKP1 (P63208)
S-phase kinase-associated protein 1 (Cyclin-A/CDK2-associated protein p19) (p19A) (Organ of Corti protein 2) (OCP-2) (Organ of Corti protein II) (OCP-II) (RNA polymerase II elongation factor-like protein) (SIII) (Transcription elongation factor B polypeptide 1-like) (p19skp1)
Gene: SKP1

Interactor 2: FXL12 (Q9NXK8)
F-box/LRR-repeat protein 12 (F-box and leucine-rich repeat protein 12) (F-box protein FBL12)
Gene: FBXL12

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.974

Property	Details
Experiments	26124079, 31257023, 35813202, 18660753, 23324393, 27705803, 27215384, 32296183, 33961781, unassigned1304
Identification Methods	affinity chromatography technology, two hybrid, pull down, two hybrid prey pooling approach, two hybrid array, validated two hybrid, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	F-box-like~Skp1
Common GO terms	GO:0005829 - cytosol GO:0016567 - protein ubiquitination GO:0019005 - SCF ubiquitin ligase complex GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 163 Hs			1 326
+	Dm
		285014 O77430_DROME (1-163): 1.01e-79: 235: 76.69		Q9VF10_DROME (4-321): 4.67e-61: 209: 21.10
+	Hs
		929092 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		FXL17_HUMAN (2-321): 8.28e-51: 180: 18.63
+	Hs
		928997 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		KDM2B_HUMAN (10-228): 1.21e-47: 173: 18.04
+	Mm
		1158242 SKP1_MOUSE (1-163): 8.88e-88: 255: 99.39		KDM2B_MOUSE (10-228): 2.43e-46: 169: 18.43
+	Hs
		928985 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		FXL16_HUMAN (9-313): 1.5e-42: 154: 15.22
+	Dm
		284994 O77430_DROME (1-163): 1.01e-79: 235: 76.69		Q8T0K1_DROME (3-295): 2.75e-48: 171: 21.36
+	Hs
		928952 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		FXL19_HUMAN (7-228): 4.88e-39: 147: 19.38
+	Mm
		1376704 SKP1_MOUSE (1-163): 8.88e-88: 255: 99.39		SKP2_MOUSE (3-288): 4.24e-39: 144: 20.28
+	Hs
		928895 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		SKP2_HUMAN (3-263): 1.26e-37: 140: 21.13
+	Dm
		284987 O77430_DROME (1-163): 1.01e-79: 235: 76.69		Q7YZ95_DROME (4-286): 1.52e-42: 156: 19.54
+	Hs
		929099 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		FBXL7_HUMAN (19-247): 8.24e-29: 117: 18.30
+	Mm
		1321913 SKP1_MOUSE (1-163): 8.88e-88: 255: 99.39		FXL20_MOUSE (68-232): 3.81e-22: 98.2: 18.50
+	Hs
		929033 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		FXL20_HUMAN (68-232): 3.59e-22: 98.2: 18.50
+	Hs
		928983 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		FXL14_HUMAN (121-326): 1.17e-20: 93.5: 21.66
+	Hs
		929109 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		FBXL4_HUMAN (41-229): 2.29e-20: 93.5: 16.24
+	Hs
		929111 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		FBXL2_HUMAN (5-206): 1.49e-15: 78.9: 16.35
+	Hs
		929057 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		FXL15_HUMAN (6-230): 3.79e-11: 64.7: 22.44
+	Mm
		58200 SKP1_MOUSE (1-163): 8.88e-88: 255: 99.39		FXL16_MOUSE (33-203): 1.07e-09: 61.2: 15.73
+	Hs
		929126 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		KDM2A_HUMAN (128-319): 4.27e-09: 59.7: 15.12
+	Dm
		284989 O77430_DROME (1-163): 1.01e-79: 235: 76.69		Q8IGU5_DROME (75-322): 1.25e-11: 67.4: 15.15