Interactor 1: SKP1 (P63208)
S-phase kinase-associated protein 1 (Cyclin-A/CDK2-associated protein p19) (p19A) (Organ of Corti protein 2) (OCP-2) (Organ of Corti protein II) (OCP-II) (RNA polymerase II elongation factor-like protein) (SIII) (Transcription elongation factor B polypeptide 1-like) (p19skp1)
Gene: SKP1
Interactor 2: FBX2 (Q9UK22)
F-box only protein 2
Gene: FBXO2
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.97 | 1.00 | 0.987 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 31210753, 32931479, 34515398, 17494702, 15109709, 18203720, 18284940, 10531037, 25416956, 27705803, 32296183, 33961781, 17389369, 19159283, 9857061, unassigned1304 |
| Identification Methods | affinity chromatography technology, pull down, two hybrid, x-ray crystallography, anti tag coimmunoprecipitation, two hybrid prey pooling approach, two hybrid array, validated two hybrid, mammalian protein protein interaction trap, tandem affinity purification |
| Interaction Type | physical association, direct interaction, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | F-box-like~Skp1, FBA~Skp1 |
| Common GO terms | GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016567 - protein ubiquitination GO:0019005 - SCF ubiquitin ligase complex GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process |
| Homologous interactions | 7 |
Homologous interactions
Color coding for hit scores 
|
|
|||||||||||||
| + | Hs |   |
|
|||||||||||
| + | Mm | |
|
|||||||||||
| + | Hs | |
|
|||||||||||
| + | Hs | |
|
|||||||||||
| + | Hs | |
|
|||||||||||
| + | Ce | |
|
|||||||||||
| + | Ce |  |
|
|||||||||||
Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
