Interactor 1: SKP1 (P63208)
S-phase kinase-associated protein 1 (Cyclin-A/CDK2-associated protein p19) (p19A) (Organ of Corti protein 2) (OCP-2) (Organ of Corti protein II) (OCP-II) (RNA polymerase II elongation factor-like protein) (SIII) (Transcription elongation factor B polypeptide 1-like) (p19skp1)
Gene: SKP1

Interactor 2: FBX9 (Q9UK97)
F-box only protein 9 (Cross-immune reaction antigen 1) (Renal carcinoma antigen NY-REN-57)
Gene: FBXO9

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.92 1.00 0.962

The method score is based on:

Property Details
Experiments 17463251, 32296183, 27705803, 33961781, 20596027, unassigned1304, 22632967
Identification Methods affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation, two hybrid prey pooling approach, two hybrid array, validated two hybrid, tandem affinity purification
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains F-box-like~Skp1
Common GO terms GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0016567 - protein ubiquitination
GO:0019005 - SCF ubiquitin ligase complex
GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
and 3 others

more...

Homologous interactions 10

Homologous interactions

Color coding for hit scores

1 163
Hs

1 447
+ Sc
+ Sp
+ At
+ At
+ At
+ At
+ At
+ At
+ At
+ At

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Last updated: 15 Jul 2024