HitPredict

Interactor 1: SKP1 (P63208)
S-phase kinase-associated protein 1 (Cyclin-A/CDK2-associated protein p19) (p19A) (Organ of Corti protein 2) (OCP-2) (Organ of Corti protein II) (OCP-II) (RNA polymerase II elongation factor-like protein) (SIII) (Transcription elongation factor B polypeptide 1-like) (p19skp1)
Gene: SKP1

Interactor 2: FBXL3 (Q9UKT7)
F-box/LRR-repeat protein 3 (F-box and leucine-rich repeat protein 3A) (F-box/LRR-repeat protein 3A)
Gene: FBXL3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	1.00	0.965

Property	Details
Experiments	10531035, 33961781, 28614300, 30596474, 32350066, 24085301, 23503662
Identification Methods	two hybrid, pull down, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	F-box-like~Skp1
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0016567 - protein ubiquitination GO:0019005 - SCF ubiquitin ligase complex GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 163 Hs			1 428
+	Mm
		1207953 SKP1_MOUSE (1-163): 8.88e-88: 255: 99.39		FBXL3_MOUSE (1-428): 0: 821: 97.20
+	Mm
		1206354 SKP1_MOUSE (1-163): 8.88e-88: 255: 99.39		FXL21_MOUSE (19-428): 0: 721: 75.18
+	Hs
		929114 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		FXL21_HUMAN (16-428): 0: 713: 72.73