HitPredict

Interactor 1: SKP1 (P63208)
S-phase kinase-associated protein 1 (Cyclin-A/CDK2-associated protein p19) (p19A) (Organ of Corti protein 2) (OCP-2) (Organ of Corti protein II) (OCP-II) (RNA polymerase II elongation factor-like protein) (SIII) (Transcription elongation factor B polypeptide 1-like) (p19skp1)
Gene: SKP1

Interactor 2: KDM2A (Q9Y2K7)
Lysine-specific demethylase 2A (EC 1.14.11.27) (CXXC-type zinc finger protein 8) (F-box and leucine-rich repeat protein 11) (F-box protein FBL7) (F-box protein Lilina) (F-box/LRR-repeat protein 11) (JmjC domain-containing histone demethylation protein 1A) ([Histone-H3]-lysine-36 demethylase 1A)
Gene: KDM2A

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	1.00	0.947

Property	Details
Experiments	27705803, 30033217, 24981860, 33961781, 17463251, 15070733
Identification Methods	affinity chromatography technology, x-ray crystallography, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	F-box-like~Skp1
Common GO terms	GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 163 Hs			1 1162
+	Hs
		928997 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		KDM2B_HUMAN (15-1162): 0: 1040: 37.75
+	Mm
		1158242 SKP1_MOUSE (1-163): 8.88e-88: 255: 99.39		KDM2B_MOUSE (1-1162): 0: 1038: 37.73
+	Hs
		928952 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		FXL19_HUMAN (538-1145): 3.09e-133: 423: 35.96
+	Mm
		1376704 SKP1_MOUSE (1-163): 8.88e-88: 255: 99.39		SKP2_MOUSE (805-1159): 1.34e-48: 181: 20.49
+	Hs
		929109 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		FBXL4_HUMAN (841-1160): 2.26e-47: 182: 15.62
+	Hs
		928895 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		SKP2_HUMAN (805-1151): 6.12e-48: 179: 19.24
+	Hs
		928985 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		FXL16_HUMAN (856-1159): 1.08e-45: 174: 17.80
+	Dm
		284987 O77430_DROME (1-163): 1.01e-79: 235: 76.69		Q7YZ95_DROME (889-1159): 4.23e-49: 186: 21.63
+	Hs
		929084 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		FXL12_HUMAN (893-1144): 8.34e-44: 164: 20.85
+	Hs
		929111 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		FBXL2_HUMAN (898-1149): 9.38e-43: 163: 19.78
+	Mm
		58200 SKP1_MOUSE (1-163): 8.88e-88: 255: 99.39		FXL16_MOUSE (714-1121): 1.76e-26: 116: 14.87
+	Mm
		1321913 SKP1_MOUSE (1-163): 8.88e-88: 255: 99.39		FXL20_MOUSE (970-1162): 2.87e-23: 106: 16.08
+	Hs
		929033 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		FXL20_HUMAN (970-1162): 1.72e-23: 106: 16.08
+	Dm
		285018 O77430_DROME (1-163): 1.01e-79: 235: 76.69		JHD1_DROME (431-568): 5.89e-28: 124: 27.54
+	Hs
		929099 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		FBXL7_HUMAN (944-1161): 6.54e-21: 99.5: 16.16
+	Hs
		929092 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		FXL17_HUMAN (970-1162): 1.4e-16: 87.2: 16.50
+	Dm
		285014 O77430_DROME (1-163): 1.01e-79: 235: 76.69		Q9VF10_DROME (691-1065): 1.1e-18: 94.2: 13.24
+	Hs
		929057 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		FXL15_HUMAN (861-1146): 7.97e-12: 69.4: 18.90
+	Hs
		928983 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		FXL14_HUMAN (773-1041): 1.21e-10: 67.2: 10.81
+	Dm
		285016 O77430_DROME (1-163): 1.01e-79: 235: 76.69		Q9VFN3_DROME (964-1144): 2.74e-16: 85.9: 23.12