HitPredict

Interactor 1: GBG1 (P63211)
Guanine nucleotide-binding protein G(T) subunit gamma-T1 (Transducin gamma chain)
Gene: GNGT1

Interactor 2: GBB4 (Q9HAV0)
Guanine nucleotide-binding protein subunit beta-4 (Transducin beta chain 4)
Gene: GNB4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	1.00	0.799

Property	Details
Experiments	33961781, 12782285
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	G-gamma~WD40
Common GO terms	GO:0005834 - heterotrimeric G-protein complex GO:0007186 - G protein-coupled receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 74 Hs			1 340
+	Hs
		921515 GBG1_HUMAN (1-74): 9.23e-28: 96.6: 100.00		GBB2_HUMAN (1-340): 1.05e-110: 327: 90.00
+	Hs
		929139 GBG1_HUMAN (1-74): 9.23e-28: 96.6: 100.00		Q6FHM2_HUMAN (1-340): 1.05e-110: 327: 90.00
+	Hs
		902497 GBG11_HUMAN (1-72): 3.87e-25: 90: 69.44		GBB4_HUMAN (1-340): 1.76e-110: 326: 100.00
+	Hs
		229238 GBG7_HUMAN (16-73): 1.84e-24: 88.1: 36.21		GBB2_HUMAN (1-340): 1.05e-110: 327: 90.00
+	Hs
		921761 GBG12_HUMAN (16-73): 3.34e-24: 87.7: 39.66		GBB2_HUMAN (1-340): 1.05e-110: 327: 90.00
+	Hs
		229245 GBG7_HUMAN (16-73): 1.84e-24: 88.1: 36.21		GBB4_HUMAN (1-340): 1.76e-110: 326: 100.00
+	Hs
		1334920 GBG12_HUMAN (16-73): 3.34e-24: 87.7: 39.66		GBB4_HUMAN (1-340): 1.76e-110: 326: 100.00
+	Bt
		362122 GBG1_BOVIN (1-74): 4.47e-28: 97.4: 98.65		GBB1_BOVIN (1-340): 1.71e-106: 316: 90.88
+	Hs
		920931 GBG1_HUMAN (1-74): 9.23e-28: 96.6: 100.00		GBB1_HUMAN (1-340): 1.71e-106: 316: 90.88
+	Hs
		560871 GBG1_HUMAN (1-74): 9.23e-28: 96.6: 100.00		GBB3_HUMAN (1-340): 1.25e-105: 314: 79.71
+	Hs
		902493 GBG11_HUMAN (1-72): 3.87e-25: 90: 69.44		GBB1_HUMAN (1-340): 1.71e-106: 316: 90.88
+	Hs
		229237 GBG7_HUMAN (16-73): 1.84e-24: 88.1: 36.21		GBB1_HUMAN (1-340): 1.71e-106: 316: 90.88
+	Hs
		560869 GBG11_HUMAN (1-72): 3.87e-25: 90: 69.44		GBB3_HUMAN (1-340): 1.25e-105: 314: 79.71
+	Hs
		921073 GBG12_HUMAN (16-73): 3.34e-24: 87.7: 39.66		GBB1_HUMAN (1-340): 1.71e-106: 316: 90.88
+	Bt
		920925 GBG2_BOVIN (16-73): 7.17e-24: 87: 39.66		GBB1_BOVIN (1-340): 1.71e-106: 316: 90.88
+	Hs
		229235 GBG7_HUMAN (16-73): 1.84e-24: 88.1: 36.21		GBB3_HUMAN (1-340): 1.25e-105: 314: 79.71
+	Hs
		560893 GBG12_HUMAN (16-73): 3.34e-24: 87.7: 39.66		GBB3_HUMAN (1-340): 1.25e-105: 314: 79.71
+	Hs
		560872 GBG3_HUMAN (16-73): 6.92e-24: 87: 37.93		GBB3_HUMAN (1-340): 1.25e-105: 314: 79.71
+	Hs
		154646 GBG7_HUMAN (16-73): 1.84e-24: 88.1: 36.21		GNB5_HUMAN (129-340): 9.12e-43: 154: 23.08
+	Hs
		154672 GBG3_HUMAN (16-73): 6.92e-24: 87: 37.93		GNB5_HUMAN (129-340): 9.12e-43: 154: 23.08