HitPredict

Interactor 1: KCNJ2 (P63252)
Inward rectifier potassium channel 2 (Cardiac inward rectifier potassium channel) (Inward rectifier K(+) channel Kir2.1) (IRK-1) (hIRK1) (Potassium channel, inwardly rectifying subfamily J member 2)
Gene: KCNJ2

Interactor 2: DLG1 (Q12959)
Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (SAP97) (hDlg)
Gene: DLG1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.602

Property	Details
Experiments	11181181, 30126976
Identification Methods	pull down, p8 filamentous phage display
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0014704 - intercalated disc GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 427 Hs			1 904
+	Rn
		1144015 KCNJ2_RAT (1-427): 0: 720: 98.83		DLG1_RAT (1-904): 0: 701: 92.54
+	Hs
		1021490 KCJ12_HUMAN (2-427): 0: 682: 69.98		DLG1_HUMAN (1-904): 0: 725: 100.00
+	Hs
		80982 KCJ18_HUMAN (2-427): 0: 675: 69.28		DLG1_HUMAN (1-904): 0: 725: 100.00
+	Rn
		852397 KCJ12_RAT (2-427): 0: 668: 70.33		DLG1_RAT (1-904): 0: 701: 92.54
+	Hs
		1054724 KCJ12_HUMAN (2-427): 0: 682: 69.98		DLG3_HUMAN (139-904): 0: 585: 66.28
+	Rn
		852399 KCJ12_RAT (2-427): 0: 668: 70.33		DLG3_RAT (99-904): 0: 590: 64.57
+	Hs
		1054729 KCJ12_HUMAN (2-427): 0: 682: 69.98		PALS2_HUMAN (421-899): 2.36e-108: 346: 23.48
+	Hs
		929762 KCNJ2_HUMAN (1-427): 0: 724: 100.00		DLG4_HUMAN (86-493): 2.62e-24: 111: 15.64
+	Hs
		929767 KCNJ2_HUMAN (1-427): 0: 724: 100.00		SCRIB_HUMAN (217-396): 1.59e-23: 109: 41.49
+	Rn
		1144360 KCNJ2_RAT (1-427): 0: 720: 98.83		DLG2_RAT (393-627): 2.93e-21: 101: 24.48
+	Hs
		159210 KCJ12_HUMAN (2-427): 0: 682: 69.98		CSKP_HUMAN (19-360): 4.23e-28: 124: 10.64
+	Rn
		852398 KCJ12_RAT (2-427): 0: 668: 70.33		CSKP_RAT (19-362): 1.15e-28: 125: 12.26
+	Hs
		942342 KCJ12_HUMAN (2-427): 0: 682: 69.98		DLG4_HUMAN (86-493): 2.62e-24: 111: 15.64
+	Hs
		1049947 KCJ12_HUMAN (2-427): 0: 682: 69.98		SCRIB_HUMAN (217-396): 1.59e-23: 109: 41.49
+	Hs
		1054723 KCJ12_HUMAN (2-427): 0: 682: 69.98		DLG2_HUMAN (393-627): 7.26e-21: 100: 24.48
+	Rn
		677769 KCJ12_RAT (2-427): 0: 668: 70.33		DLG4_RAT (86-493): 2.93e-24: 111: 15.40
+	Rn
		852400 KCJ12_RAT (2-427): 0: 668: 70.33		DLG2_RAT (393-627): 2.93e-21: 101: 24.48
+	Hs
		159173 KCNJ4_HUMAN (30-427): 0: 590: 59.82		CSKP_HUMAN (19-360): 4.23e-28: 124: 10.64
+	Mm
		852403 KCNJ4_MOUSE (31-427): 0: 601: 59.64		DLG4_MOUSE (86-477): 2.03e-24: 111: 16.07
+	Hs
		816146 KCNJ4_HUMAN (30-427): 0: 590: 59.82		DLG4_HUMAN (86-493): 2.62e-24: 111: 15.64