HitPredict

Interactor 1: ACTG (P63261)
Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed]
Gene: ACTG1

Interactor 2: TRAF2 (Q12933)
TNF receptor-associated factor 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF2) (RING-type E3 ubiquitin transferase TRAF2) (Tumor necrosis factor type 2 receptor-associated protein 3)
Gene: TRAF2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	30561431, 14743216
Identification Methods	affinity chromatography technology, virotrap, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019901 - protein kinase binding GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 375 Hs			1 501
+	Mm
		892159 ACTB_MOUSE (1-375): 0: 604: 98.93		TRAF6_MOUSE (2-498): 2.51e-110: 339: 27.87
+	Hs
		930065 ACTG_HUMAN (1-375): 0: 604: 100.00		TRAF6_HUMAN (2-498): 5.24e-109: 335: 27.08
+	Hs
		929840 ACTG_HUMAN (1-375): 0: 604: 100.00		TRAF1_HUMAN (130-499): 1.15e-88: 279: 37.44
+	Hs
		584915 ACTB_HUMAN (1-375): 0: 604: 98.93		RO52_HUMAN (28-368): 2.44e-56: 196: 12.68
+	Hs
		584922 ACTA_HUMAN (2-375): 0: 594: 94.39		RO52_HUMAN (28-368): 2.44e-56: 196: 12.68
+	Hs
		933049 ACTS_HUMAN (2-375): 0: 594: 93.85		TRIM6_HUMAN (27-360): 2.88e-47: 172: 13.71
+	Hs
		930096 ACTH_HUMAN (2-375): 0: 592: 94.39		TRIM6_HUMAN (27-360): 2.88e-47: 172: 13.71
+	Hs
		891904 ACTB_HUMAN (1-375): 0: 604: 98.93		TRI58_HUMAN (26-368): 4.13e-40: 152: 13.76
+	Hs
		891966 ACTB_HUMAN (1-375): 0: 604: 98.93		RN125_HUMAN (32-167): 6.6e-34: 129: 21.83