HitPredict

Interactor 1: ACTH (P63267)
Actin, gamma-enteric smooth muscle (EC 3.6.4.-) (Alpha-actin-3) (Gamma-2-actin) (Smooth muscle gamma-actin) [Cleaved into: Actin, gamma-enteric smooth muscle, intermediate form]
Gene: ACTG2

Interactor 2: LRRK2 (Q5S007)
Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)
Gene: LRRK2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	20876399
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Actin~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005615 - extracellular space GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005856 - cytoskeleton and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 376 Hs			1 2527
+	Hs
		1122417 ACTBL_HUMAN (1-376): 0: 713: 87.77		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		891823 ACTB_HUMAN (1-376): 0: 601: 93.35		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		929893 ACTG_HUMAN (3-376): 0: 601: 94.39		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		932198 ACTC_HUMAN (2-376): 0: 598: 98.67		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		932992 ACTS_HUMAN (2-376): 0: 598: 98.13		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		915405 ACTA_HUMAN (1-376): 0: 595: 99.20		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Mm
		1130112 ACTBL_MOUSE (1-376): 0: 721: 88.83		LRRK2_MOUSE (1-2527): 0: 2865: 86.09
+	Mm
		892172 ACTB_MOUSE (1-376): 0: 601: 93.35		LRRK2_MOUSE (1-2527): 0: 2865: 86.09
+	Mm
		929787 ACTG_MOUSE (3-376): 0: 601: 94.39		LRRK2_MOUSE (1-2527): 0: 2865: 86.09
+	Hs
		201296 ACTG_HUMAN (3-376): 0: 601: 94.39		M3K7_HUMAN (1869-2132): 8.36e-23: 107: 28.83