HitPredict

Interactor 1: UBC9 (P63279)
SUMO-conjugating enzyme UBC9 (EC 2.3.2.-) (RING-type E3 SUMO transferase UBC9) (SUMO-protein ligase) (Ubiquitin carrier protein 9) (Ubiquitin carrier protein I) (Ubiquitin-conjugating enzyme E2 I) (Ubiquitin-protein ligase I) (p18)
Gene: UBE2I

Interactor 2: XIAP (P98170)
E3 ubiquitin-protein ligase XIAP (EC 2.3.2.27) (Baculoviral IAP repeat-containing protein 4) (IAP-like protein) (ILP) (hILP) (Inhibitor of apoptosis protein 3) (IAP-3) (hIAP-3) (hIAP3) (RING-type E3 ubiquitin transferase XIAP) (X-linked inhibitor of apoptosis protein) (X-linked IAP)
Gene: XIAP

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	21113135
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4_3
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 158 Hs			1 497
+	Hs
		957802 UB2D4_HUMAN (4-157): 3.74e-75: 222: 34.42		XIAP_HUMAN (1-497): 0: 569: 100.00
+	Hs
		849308 UB2D1_HUMAN (4-157): 7.96e-75: 221: 33.12		XIAP_HUMAN (1-497): 0: 569: 100.00
+	Hs
		849322 UB2D1_HUMAN (4-157): 7.96e-75: 221: 33.12		BIRC2_HUMAN (3-497): 9.73e-82: 267: 23.31
+	Hs
		849321 UB2D1_HUMAN (4-157): 7.96e-75: 221: 33.12		BIRC3_HUMAN (150-394): 2.89e-41: 158: 23.94
+	Hs
		849400 UB2D1_HUMAN (4-157): 7.96e-75: 221: 33.12		BIRC7_HUMAN (14-155): 1.47e-36: 138: 21.83
+	Ce
		72455 UBC2_CAEEL (4-157): 4.4e-74: 220: 35.71		B3WFX6_CAEEL (221-493): 2.31e-30: 126: 11.50
+	Hs
		1298970 UB2D4_HUMAN (4-157): 3.74e-75: 222: 34.42		BIRC8_HUMAN (160-264): 3.74e-31: 122: 30.48
+	Hs
		849413 UB2D1_HUMAN (4-157): 7.96e-75: 221: 33.12		BIRC8_HUMAN (160-264): 3.74e-31: 122: 30.48
+	Hs
		849456 UB2D1_HUMAN (4-157): 7.96e-75: 221: 33.12		BIRC6_HUMAN (258-442): 3.1e-26: 115: 18.78
+	Hs
		1165227 UB2D4_HUMAN (4-157): 3.74e-75: 222: 34.42		LRSM1_HUMAN (330-497): 2.09e-24: 108: 18.45
+	Hs
		1316184 UB2D4_HUMAN (4-157): 3.74e-75: 222: 34.42		RNF26_HUMAN (320-496): 6.59e-25: 108: 14.13
+	Hs
		849345 UB2D1_HUMAN (4-157): 7.96e-75: 221: 33.12		LRSM1_HUMAN (330-497): 2.09e-24: 108: 18.45
+	Hs
		849431 UB2D1_HUMAN (4-157): 7.96e-75: 221: 33.12		RNF26_HUMAN (320-496): 6.59e-25: 108: 14.13
+	Hs
		1264347 UB2D4_HUMAN (4-157): 3.74e-75: 222: 34.42		MYLIP_HUMAN (430-496): 3.78e-23: 103: 35.82
+	Hs
		849386 UB2D1_HUMAN (4-157): 7.96e-75: 221: 33.12		MYLIP_HUMAN (430-496): 3.78e-23: 103: 35.82
+	Hs
		849387 UB2D1_HUMAN (4-157): 7.96e-75: 221: 33.12		RFFL_HUMAN (446-497): 3.49e-18: 88: 44.23
+	Hs
		1206094 UB2D4_HUMAN (4-157): 3.74e-75: 222: 34.42		MIB1_HUMAN (311-492): 5.04e-16: 83.1: 13.68
+	Dm
		639392 UBCD1_DROME (4-157): 4.5e-74: 220: 35.71		DIAP1_DROME (243-424): 7.45e-17: 84.6: 20.21
+	Hs
		849363 UB2D1_HUMAN (4-157): 7.96e-75: 221: 33.12		MIB1_HUMAN (311-492): 5.04e-16: 83.1: 13.68
+	Hs
		849396 UB2D1_HUMAN (4-157): 7.96e-75: 221: 33.12		MIB2_HUMAN (437-496): 2e-10: 65.3: 35.00