HitPredict

Interactor 1: UBC9 (P63279)
SUMO-conjugating enzyme UBC9 (EC 2.3.2.-) (RING-type E3 SUMO transferase UBC9) (SUMO-protein ligase) (Ubiquitin carrier protein 9) (Ubiquitin carrier protein I) (Ubiquitin-conjugating enzyme E2 I) (Ubiquitin-protein ligase I) (p18)
Gene: UBE2I

Interactor 2: PPARA (Q07869)
Peroxisome proliferator-activated receptor alpha (PPAR-alpha) (Nuclear receptor subfamily 1 group C member 1)
Gene: PPARA

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	19955185
Identification Methods	enzymatic study, pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 158 Hs			1 468
+	Hs
		587151 UBC9_HUMAN (1-158): 1.43e-70: 211: 100.00		RXRA_HUMAN (2-465): 5.7e-118: 355: 21.61
+	Hs
		849297 UB2D1_HUMAN (4-157): 7.96e-75: 221: 33.12		NR1H2_HUMAN (19-464): 4.66e-112: 340: 22.93
+	Hs
		500477 UBC9_HUMAN (1-158): 1.43e-70: 211: 100.00		THB_HUMAN (99-466): 3.59e-114: 345: 27.42
+	Hs
		740497 UBC9_HUMAN (1-158): 1.43e-70: 211: 100.00		PPARG_HUMAN (1-468): 2.71e-112: 342: 54.36
+	Hs
		874374 UBC9_HUMAN (1-158): 1.43e-70: 211: 100.00		NR1H2_HUMAN (19-464): 4.66e-112: 340: 22.93
+	Hs
		369363 UBC9_HUMAN (1-158): 1.43e-70: 211: 100.00		ESR1_HUMAN (11-464): 2.21e-107: 332: 18.30
+	Hs
		930186 UBC9_HUMAN (1-158): 1.43e-70: 211: 100.00		NR1H3_HUMAN (6-464): 2.51e-109: 332: 23.70
+	Hs
		782515 UBC9_HUMAN (1-158): 1.43e-70: 211: 100.00		HNF4A_HUMAN (77-464): 1.45e-103: 318: 22.11
+	Hs
		265861 UBC9_HUMAN (1-158): 1.43e-70: 211: 100.00		NR1I2_HUMAN (79-464): 2.55e-103: 316: 24.46