HitPredict

Interactor 1: UBC9 (P63279)
SUMO-conjugating enzyme UBC9 (EC 2.3.2.-) (RING-type E3 SUMO transferase UBC9) (SUMO-protein ligase) (Ubiquitin carrier protein 9) (Ubiquitin carrier protein I) (Ubiquitin-conjugating enzyme E2 I) (Ubiquitin-protein ligase I) (p18)
Gene: UBE2I

Interactor 2: SRBP2 (Q12772)
Sterol regulatory element-binding protein 2 (SREBP-2) (Class D basic helix-loop-helix protein 2) (bHLHd2) (Sterol regulatory element-binding transcription factor 2) [Cleaved into: Processed sterol regulatory element-binding protein 2 (Transcription factor SREBF2)]
Gene: SREBF2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.614

Property	Details
Experiments	12615929, 20936779
Identification Methods	affinity chromatography technology, two hybrid, two hybrid pooling approach
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 158 Hs			1 1141
+	Hs
		738953 UBC9_HUMAN (1-158): 1.43e-70: 211: 100.00		SRBP1_HUMAN (1-1141): 0: 870: 43.72
+	Hs
		252916 UBC9_HUMAN (1-158): 1.43e-70: 211: 100.00		MITF_HUMAN (55-441): 3.85e-34: 140: 17.04
+	Hs
		849390 UB2D1_HUMAN (4-157): 7.96e-75: 221: 33.12		CBP_HUMAN (5-492): 1.07e-29: 130: 12.88
+	Hs
		930327 UBC9_HUMAN (1-158): 1.43e-70: 211: 100.00		CBP_HUMAN (5-492): 1.07e-29: 130: 12.88
+	Hs
		930269 UBC9_HUMAN (1-158): 1.43e-70: 211: 100.00		MCAF1_HUMAN (17-480): 6.91e-28: 124: 12.42
+	Hs
		72109 UBC9_HUMAN (1-158): 1.43e-70: 211: 100.00		B3KQF8_HUMAN (17-480): 2.36e-25: 115: 12.42
+	Hs
		849313 UB2D1_HUMAN (4-157): 7.96e-75: 221: 33.12		EP300_HUMAN (13-430): 1.85e-13: 77.7: 8.50
+	Hs
		930176 UBC9_HUMAN (1-158): 1.43e-70: 211: 100.00		EP300_HUMAN (13-430): 1.85e-13: 77.7: 8.50