HitPredict

Interactor 1: UBC9 (P63279)
SUMO-conjugating enzyme UBC9 (EC 2.3.2.-) (RING-type E3 SUMO transferase UBC9) (SUMO-protein ligase) (Ubiquitin carrier protein 9) (Ubiquitin carrier protein I) (Ubiquitin-conjugating enzyme E2 I) (Ubiquitin-protein ligase I) (p18)
Gene: UBE2I

Interactor 2: NR1H3 (Q13133)
Oxysterols receptor LXR-alpha (Liver X receptor alpha) (Nuclear receptor subfamily 1 group H member 3)
Gene: NR1H3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	27485016
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 158 Hs			1 447
+	Hs
		849297 UB2D1_HUMAN (4-157): 7.96e-75: 221: 33.12		NR1H2_HUMAN (12-447): 3.47e-127: 377: 61.96
+	Hs
		587151 UBC9_HUMAN (1-158): 1.43e-70: 211: 100.00		RXRA_HUMAN (6-445): 5.73e-129: 382: 22.89
+	Hs
		874374 UBC9_HUMAN (1-158): 1.43e-70: 211: 100.00		NR1H2_HUMAN (12-447): 3.47e-127: 377: 61.96
+	Hs
		369363 UBC9_HUMAN (1-158): 1.43e-70: 211: 100.00		ESR1_HUMAN (6-446): 3.36e-116: 354: 20.04
+	Hs
		782515 UBC9_HUMAN (1-158): 1.43e-70: 211: 100.00		HNF4A_HUMAN (74-443): 1.56e-112: 340: 26.08
+	Hs
		740497 UBC9_HUMAN (1-158): 1.43e-70: 211: 100.00		PPARG_HUMAN (69-443): 3.18e-108: 330: 27.64
+	Hs
		930168 UBC9_HUMAN (1-158): 1.43e-70: 211: 100.00		PPARA_HUMAN (5-443): 6.93e-102: 313: 25.43
+	Hs
		500477 UBC9_HUMAN (1-158): 1.43e-70: 211: 100.00		THB_HUMAN (36-444): 7.14e-98: 302: 28.81
+	Hs
		500407 UBC9_HUMAN (1-158): 1.43e-70: 211: 100.00		THA_HUMAN (95-410): 1.92e-49: 177: 34.05
+	Hs
		265861 UBC9_HUMAN (1-158): 1.43e-70: 211: 100.00		NR1I2_HUMAN (75-445): 8.74e-49: 174: 29.67