HitPredict

Interactor 1: UBC9 (P63279)
SUMO-conjugating enzyme UBC9 (EC 2.3.2.-) (RING-type E3 SUMO transferase UBC9) (SUMO-protein ligase) (Ubiquitin carrier protein 9) (Ubiquitin carrier protein I) (Ubiquitin-conjugating enzyme E2 I) (Ubiquitin-protein ligase I) (p18)
Gene: UBE2I

Interactor 2: IKZF1 (Q13422)
DNA-binding protein Ikaros (Ikaros family zinc finger protein 1) (Lymphoid transcription factor LyF-1)
Gene: IKZF1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.686

Property	Details
Experiments	30217970, 25416956, 16189514, 32296183
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 158 Hs			1 519
+	Hs
		1033668 Q7KZS0_HUMAN (1-137): 2.27e-71: 214: 100.00		IKZF1_HUMAN (1-519): 0: 664: 100.00
+	Mm
		930484 UBC9_MOUSE (1-158): 1.43e-70: 211: 100.00		IKZF1_MOUSE (1-519): 0: 611: 91.57
+	Mm
		140044 UBC9_MOUSE (1-158): 1.43e-70: 211: 100.00		IKZF3_MOUSE (13-515): 1.73e-144: 426: 53.70
+	Hs
		930448 UBC9_HUMAN (1-158): 1.43e-70: 211: 100.00		IKZF3_HUMAN (11-515): 4.42e-139: 413: 53.82
+	Hs
		930306 UBC9_HUMAN (1-158): 1.43e-70: 211: 100.00		ZN420_HUMAN (441-519): 2.85e-23: 105: 22.79
+	Hs
		930394 UBC9_HUMAN (1-158): 1.43e-70: 211: 100.00		IKZF5_HUMAN (62-193): 1.16e-11: 68.6: 33.33
+	Dm
		592800 Q7KNM2_DROME (1-158): 1.41e-66: 201: 85.44		CF2_DROME (117-191): 1.44e-10: 65.5: 41.33