HitPredict

Interactor 1: UBC9 (P63279)
SUMO-conjugating enzyme UBC9 (EC 2.3.2.-) (RING-type E3 SUMO transferase UBC9) (SUMO-protein ligase) (Ubiquitin carrier protein 9) (Ubiquitin carrier protein I) (Ubiquitin-conjugating enzyme E2 I) (Ubiquitin-protein ligase I) (p18)
Gene: UBE2I

Interactor 2: TOPRS (Q9NS56)
E3 ubiquitin-protein ligase Topors (EC 2.3.2.27) (RING-type E3 ubiquitin transferase Topors) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3)
Gene: TOPORS

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.767

Property	Details
Experiments	16122737, 14516784
Identification Methods	pull down, two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006511 - ubiquitin-dependent protein catabolic process GO:0016605 - PML body GO:0016925 - protein sumoylation and 1 others more... GO:0019789 - SUMO transferase activity
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 158 Hs			1 1045
+	Hs
		1345306 UB2D4_HUMAN (4-157): 3.74e-75: 222: 34.42		TOPRS_HUMAN (1-1045): 0: 731: 100.00
+	Hs
		849457 UB2D1_HUMAN (4-157): 7.96e-75: 221: 33.12		TOPRS_HUMAN (1-1045): 0: 731: 100.00
+	Hs
		919873 UB2D2_HUMAN (4-157): 2.44e-74: 220: 35.07		TOPRS_HUMAN (1-1045): 0: 731: 100.00
+	Hs
		895925 UB2D3_HUMAN (4-157): 6.67e-73: 216: 35.07		TOPRS_HUMAN (1-1045): 0: 731: 100.00
+	Hs
		1282352 UB2E3_HUMAN (3-156): 2.14e-68: 207: 33.77		TOPRS_HUMAN (1-1045): 0: 731: 100.00
+	Hs
		851891 UB2E1_HUMAN (3-156): 7.23e-67: 203: 33.12		TOPRS_HUMAN (1-1045): 0: 731: 100.00