HitPredict

Interactor 1: PP2AA (P63330)
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PP2A-alpha) (EC 3.1.3.16)
Gene: Ppp2ca

Interactor 2: NEB2 (Q6R891)
Neurabin-2 (Neurabin-II) (Protein phosphatase 1 regulatory subunit 9B) (Spinophilin)
Gene: Ppp1r9b

Species: Mus musculus

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	30562941
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Metallophos~PDZ, Metallophos~PDZ_5
Common GO terms	GO:0001932 - regulation of protein phosphorylation GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0044325 - transmembrane transporter binding GO:0044877 - protein-containing complex binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 309 Mm			1 817
+	Mm
		915331 PP2AB_MOUSE (1-309): 0: 529: 97.41		NEB2_MOUSE (1-817): 1.3e-116: 374: 100.00
+	Rn
		192521 PP1G_RAT (4-306): 0: 505: 45.51		NEB2_RAT (1-817): 2.42e-118: 379: 98.90
+	Rn
		192519 PP1A_RAT (4-296): 0: 503: 46.36		NEB2_RAT (1-817): 2.42e-118: 379: 98.90
+	Mm
		926545 PP1G_MOUSE (4-306): 0: 505: 45.51		NEB2_MOUSE (1-817): 1.3e-116: 374: 100.00
+	Mm
		906288 PP1A_MOUSE (4-296): 0: 503: 46.69		NEB2_MOUSE (1-817): 1.3e-116: 374: 100.00
+	Hs
		737997 PP1G_HUMAN (4-306): 0: 505: 45.83		NEB2_HUMAN (1-817): 5.5e-113: 365: 95.84
+	Hs
		906098 PP1A_HUMAN (4-296): 0: 503: 46.36		NEB2_HUMAN (1-817): 5.5e-113: 365: 95.84
+	Hs
		738120 PP1G_HUMAN (4-306): 0: 505: 45.83		NEB1_HUMAN (1-817): 1.2e-100: 338: 46.50
+	Hs
		906197 PP1A_HUMAN (4-296): 0: 503: 46.36		NEB1_HUMAN (1-817): 1.2e-100: 338: 46.50
+	Rn
		193534 PP1G_RAT (4-306): 0: 505: 45.51		NEB1_RAT (1-817): 1.17e-92: 316: 45.86
+	Mm
		930640 PP2AA_MOUSE (1-309): 0: 530: 100.00		ERBIN_MOUSE (40-585): 1.14e-39: 160: 13.73
+	Hs
		930930 PP2AA_HUMAN (1-309): 0: 531: 99.68		LNX1_HUMAN (224-773): 4.36e-33: 138: 11.92
+	Hs
		906059 PP1A_HUMAN (4-296): 0: 503: 46.36		DLG3_HUMAN (269-734): 1.64e-40: 162: 16.36
+	Mm
		926531 PP1G_MOUSE (4-306): 0: 505: 45.51		DLG3_MOUSE (224-734): 1.59e-39: 159: 16.23
+	Mm
		915328 PP2AB_MOUSE (1-309): 0: 529: 97.41		DLG4_MOUSE (381-806): 1.83e-31: 133: 11.04
+	Hs
		737775 PP1G_HUMAN (4-306): 0: 505: 45.83		DLG1_HUMAN (80-763): 3.75e-33: 139: 11.22
+	Hs
		906031 PP1A_HUMAN (4-296): 0: 503: 46.36		LNX1_HUMAN (224-773): 4.36e-33: 138: 11.92
+	Mm
		906274 PP1A_MOUSE (4-296): 0: 503: 46.69		DLG4_MOUSE (381-806): 1.83e-31: 133: 11.04
+	Hs
		905921 PP1A_HUMAN (4-296): 0: 503: 46.36		DLG2_HUMAN (413-817): 2.76e-25: 114: 14.35