HitPredict

Interactor 1: PP2AA (P67775)
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PP2A-alpha) (EC 3.1.3.16) (Replication protein C) (RP-C)
Gene: PPP2CA

Interactor 2: AAPK1 (Q13131)
5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRKAA1) (EC 2.7.11.26)
Gene: PRKAA1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	16306228, 22065577
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0046872 - metal ion binding GO:0048156 - tau protein binding
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 309 Hs			1 559
+	Rn
		871244 PP2AA_RAT (1-309): 0: 528: 99.68		AAPK1_RAT (1-559): 0: 593: 99.11
+	Rn
		871210 PP1A_RAT (5-296): 0: 504: 46.51		AAPK1_RAT (1-559): 0: 593: 99.11
+	Hs
		647866 PP2AB_HUMAN (1-309): 0: 528: 97.41		MARK3_HUMAN (3-543): 7.31e-144: 434: 28.21
+	Hs
		915261 PP2AB_HUMAN (1-309): 0: 528: 97.41		MARK4_HUMAN (18-543): 9.01e-140: 424: 28.76
+	Sc
		419801 PP11_YEAST (11-309): 1.47e-137: 393: 57.71		SNF1_YEAST (23-475): 3.4e-141: 424: 38.62
+	Hs
		930991 PP2AA_HUMAN (1-309): 0: 529: 100.00		SIK2_HUMAN (10-340): 1.75e-85: 286: 42.69
+	Hs
		738035 PP1G_HUMAN (7-306): 0: 505: 45.96		SIK2_HUMAN (10-340): 1.75e-85: 286: 42.69
+	Hs
		906123 PP1A_HUMAN (5-296): 0: 504: 46.51		SIK2_HUMAN (10-340): 1.75e-85: 286: 42.69