HitPredict

Interactor 1: YBOX1 (P67809)
Y-box-binding protein 1 (YB-1) (CCAAT-binding transcription factor I subunit A) (CBF-A) (DNA-binding protein B) (DBPB) (Enhancer factor I subunit A) (EFI-A) (Nuclease-sensitive element-binding protein 1) (Y-box transcription factor)
Gene: YBX1

Interactor 2: SRSF5 (Q13243)
Serine/arginine-rich splicing factor 5 (Delayed-early protein HRS) (Pre-mRNA-splicing factor SRP40) (Splicing factor, arginine/serine-rich 5)
Gene: SRSF5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	CSD~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0003729 - mRNA binding GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0006397 - mRNA processing
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 324 Hs			1 272
+	Hs
		931111 YBOX1_HUMAN (1-324): 4.21e-69: 220: 100.00		SRSF1_HUMAN (2-170): 6.55e-57: 184: 43.68
+	Hs
		66328 YBOX1_HUMAN (1-324): 4.21e-69: 220: 100.00		A8K1L8_HUMAN (2-170): 2.53e-56: 183: 42.53
+	Hs
		931130 YBOX1_HUMAN (1-324): 4.21e-69: 220: 100.00		SRSF9_HUMAN (2-211): 1.47e-52: 172: 33.02
+	Hs
		931132 YBOX1_HUMAN (1-324): 4.21e-69: 220: 100.00		SRSF6_HUMAN (5-184): 1.35e-48: 165: 61.96
+	Hs
		563079 YBOX3_HUMAN (46-324): 2.21e-55: 186: 51.69		SRSF1_HUMAN (2-170): 6.55e-57: 184: 43.68
+	Hs
		992817 LN28B_HUMAN (33-275): 3.38e-55: 182: 24.41		SRSF1_HUMAN (2-170): 6.55e-57: 184: 43.68
+	Hs
		563084 YBOX3_HUMAN (46-324): 2.21e-55: 186: 51.69		SRSF5_HUMAN (1-240): 2.63e-54: 178: 100.00
+	Hs
		1028703 LN28B_HUMAN (33-275): 3.38e-55: 182: 24.41		SRSF5_HUMAN (1-240): 2.63e-54: 178: 100.00
+	Hs
		563085 YBOX3_HUMAN (46-324): 2.21e-55: 186: 51.69		SRSF6_HUMAN (5-184): 1.35e-48: 165: 61.96
+	Hs
		993000 YBOX2_HUMAN (23-314): 7.22e-48: 166: 44.15		SRSF1_HUMAN (2-170): 6.55e-57: 184: 43.68
+	Hs
		993874 YBOX2_HUMAN (23-314): 7.22e-48: 166: 44.15		SRSF4_HUMAN (5-265): 3.78e-51: 176: 53.64
+	Hs
		931135 YBOX1_HUMAN (1-324): 4.21e-69: 220: 100.00		PABP4_HUMAN (104-189): 3.45e-16: 80.1: 21.98
+	Hs
		516455 YBOX1_HUMAN (1-324): 4.21e-69: 220: 100.00		PABP1_HUMAN (98-189): 1.16e-15: 78.6: 18.56
+	Hs
		931406 YBOX1_HUMAN (1-324): 4.21e-69: 220: 100.00		PABP3_HUMAN (98-189): 8.72e-15: 75.9: 18.56
+	Hs
		474013 YBOX1_HUMAN (1-324): 4.21e-69: 220: 100.00		PAB4L_HUMAN (5-75): 5.48e-14: 72.8: 24.68
+	Hs
		931095 YBOX1_HUMAN (1-324): 4.21e-69: 220: 100.00		SRSF3_HUMAN (4-78): 1.85e-11: 62.8: 47.56
+	Hs
		516350 YBOX3_HUMAN (46-324): 2.21e-55: 186: 51.69		PABP1_HUMAN (98-189): 1.16e-15: 78.6: 18.56
+	Hs
		474028 LN28B_HUMAN (33-275): 3.38e-55: 182: 24.41		PAB4L_HUMAN (5-75): 5.48e-14: 72.8: 24.68
+	Hs
		563070 YBOX3_HUMAN (46-324): 2.21e-55: 186: 51.69		SRSF3_HUMAN (4-78): 1.85e-11: 62.8: 47.56
+	Hs
		474045 YBOX2_HUMAN (23-314): 7.22e-48: 166: 44.15		PAB4L_HUMAN (5-75): 5.48e-14: 72.8: 24.68