HitPredict

Interactor 1: YBOX1 (P67809)
Y-box-binding protein 1 (YB-1) (CCAAT-binding transcription factor I subunit A) (CBF-A) (DNA-binding protein B) (DBPB) (Enhancer factor I subunit A) (EFI-A) (Nuclease-sensitive element-binding protein 1) (Y-box transcription factor)
Gene: YBX1

Interactor 2: E4F1 (Q66K89)
Transcription factor E4F1 (EC 2.3.2.27) (E4F transcription factor 1) (Putative E3 ubiquitin-protein ligase E4F1) (RING-type E3 ubiquitin transferase E4F1) (Transcription factor E4F) (p120E4F) (p50E4F)
Gene: E4F1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 324 Hs			1 784
+	Hs
		563124 YBOX3_HUMAN (46-324): 2.21e-55: 186: 51.69		E4F1_HUMAN (1-784): 0: 590: 100.00
+	Hs
		931362 YBOX1_HUMAN (1-324): 4.21e-69: 220: 100.00		ZN184_HUMAN (2-272): 1.02e-108: 350: 17.50
+	Hs
		1305555 YBOX2_HUMAN (23-314): 7.22e-48: 166: 44.15		ZN184_HUMAN (2-272): 1.02e-108: 350: 17.50
+	Hs
		931344 YBOX1_HUMAN (1-324): 4.21e-69: 220: 100.00		ZN514_HUMAN (192-268): 7.29e-12: 70.1: 38.96
+	Hs
		931435 YBOX1_HUMAN (1-324): 4.21e-69: 220: 100.00		PRDM9_HUMAN (192-271): 5.87e-09: 61.6: 36.25
+	Hs
		1350393 YBOX2_HUMAN (23-314): 7.22e-48: 166: 44.15		ZN624_HUMAN (2-55): 1.11e-09: 64: 12.96
+	Hs
		563313 LN28A_HUMAN (50-217): 1.06e-42: 148: 23.46		ZNF16_HUMAN (621-770): 1.71e-13: 76.3: 7.33