HitPredict

Interactor 1: ACTC (P68032)
Actin, alpha cardiac muscle 1 (EC 3.6.4.-) (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form]
Gene: ACTC1

Interactor 2: SPTN1 (Q13813)
Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit)
Gene: SPTAN1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	30890647
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0016020 - membrane GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 377 Hs			1 2472
+	Hs
		891755 ACTB_HUMAN (4-377): 0: 599: 94.12		SPTN1_HUMAN (1-2472): 0: 714: 100.00
+	Hs
		929856 ACTG_HUMAN (4-377): 0: 599: 94.39		SPTN1_HUMAN (1-2472): 0: 714: 100.00
+	Hs
		932975 ACTS_HUMAN (1-377): 0: 599: 98.94		SPTN1_HUMAN (1-2472): 0: 714: 100.00
+	Dm
		361165 ACT4_DROME (1-377): 0: 649: 92.57		SPTCA_DROME (3-2472): 1.26e-174: 598: 63.92
+	Hs
		360636 ACTS_HUMAN (1-377): 0: 599: 98.94		SPTA1_HUMAN (1-2472): 2.98e-159: 552: 54.81
+	Dm
		361167 ACT4_DROME (1-377): 0: 649: 92.57		ACTN_DROME (1864-2470): 1.19e-77: 281: 30.27
+	Hs
		164588 ACTB_HUMAN (4-377): 0: 599: 94.12		SPTN2_HUMAN (141-1932): 1.25e-65: 250: 20.41
+	Hs
		891697 ACTB_HUMAN (4-377): 0: 599: 94.12		SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52
+	Hs
		929824 ACTG_HUMAN (4-377): 0: 599: 94.39		SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52
+	Hs
		932107 ACTC_HUMAN (1-377): 0: 599: 100.00		SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52
+	Hs
		891706 ACTB_HUMAN (4-377): 0: 599: 94.12		DYST_HUMAN (5-2410): 1.41e-35: 152: 10.59
+	Hs
		932113 ACTC_HUMAN (1-377): 0: 599: 100.00		DYST_HUMAN (5-2410): 1.41e-35: 152: 10.59
+	Hs
		929869 ACTG_HUMAN (4-377): 0: 599: 94.39		PLEC_HUMAN (16-1253): 4.4e-31: 137: 9.18
+	Hs
		892113 ACTB_HUMAN (4-377): 0: 599: 94.12		MACF1_HUMAN (9-1261): 9.1e-18: 93.6: 12.48
+	Hs
		506816 ACTB_HUMAN (4-377): 0: 599: 94.12		SPTB1_HUMAN (1743-2409): 3.32e-13: 78.1: 19.70
+	Hs
		828573 ACTC_HUMAN (1-377): 0: 599: 100.00		CENPF_HUMAN (1723-2444): 8.12e-13: 77: 9.28
+	Hs
		892003 ACTB_HUMAN (4-377): 0: 599: 94.12		CP250_HUMAN (1768-2439): 4.39e-10: 67.7: 8.94
+	Hs
		211548 ACTB_HUMAN (4-377): 0: 599: 94.12		ACTN4_HUMAN (1843-2219): 1.15e-09: 66.2: 20.15
+	Hs
		211560 ACTC_HUMAN (1-377): 0: 599: 100.00		ACTN4_HUMAN (1843-2219): 1.15e-09: 66.2: 20.15
+	Hs
		211561 ACTS_HUMAN (1-377): 0: 599: 98.94		ACTN4_HUMAN (1843-2219): 1.15e-09: 66.2: 20.15