HitPredict

Interactor 1: ACTC (P68032)
Actin, alpha cardiac muscle 1 (EC 3.6.4.-) (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form]
Gene: ACTC1

Interactor 2: SRCAP (Q6ZRS2)
Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator)
Gene: SRCAP

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	30890647
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Actin~HSA, Actin~SNF2-rel_dom
Common GO terms	GO:0005524 - ATP binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 377 Hs			1 3230
+	Hs
		891853 ACTB_HUMAN (4-377): 0: 599: 94.12		SRCAP_HUMAN (1-3230): 0: 1210: 100.00
+	Hs
		929905 ACTG_HUMAN (4-377): 0: 599: 94.39		SRCAP_HUMAN (1-3230): 0: 1210: 100.00
+	Hs
		891769 ACTB_HUMAN (4-377): 0: 599: 94.12		CHD4_HUMAN (1959-2633): 3.48e-89: 328: 19.60
+	Hs
		932158 ACTC_HUMAN (1-377): 0: 599: 100.00		CHD4_HUMAN (1959-2633): 3.48e-89: 328: 19.60
+	Hs
		229358 ACTC_HUMAN (1-377): 0: 599: 100.00		SMCA5_HUMAN (2003-2357): 1.13e-90: 323: 28.77
+	Sp
		142452 ACT_SCHPO (4-377): 0: 645: 89.04		SWR1_SCHPO (2039-2346): 3.61e-72: 269: 46.43
+	Hs
		892104 ACTB_HUMAN (4-377): 0: 599: 94.12		INO80_HUMAN (1894-2441): 1.39e-72: 272: 24.19
+	Sp
		144858 ACT_SCHPO (4-377): 0: 645: 89.04		INO80_SCHPO (1955-2216): 3.12e-57: 223: 33.33
+	Xl
		292752 ACTB_XENLA (4-377): 0: 598: 94.12		Q4VQ79_XENLA (2010-2446): 4.54e-65: 248: 23.18
+	Hs
		846910 ACTB_HUMAN (4-377): 0: 599: 94.12		SMCA4_HUMAN (1505-1858): 9.38e-13: 76.9: 13.22
+	Hs
		846917 ACTG_HUMAN (4-377): 0: 599: 94.39		SMCA4_HUMAN (1505-1858): 9.38e-13: 76.9: 13.22
+	Hs
		846918 ACTC_HUMAN (1-377): 0: 599: 100.00		SMCA4_HUMAN (1505-1858): 9.38e-13: 76.9: 13.22
+	Hs
		846919 ACTS_HUMAN (1-377): 0: 599: 98.94		SMCA4_HUMAN (1505-1858): 9.38e-13: 76.9: 13.22
+	Hs
		891979 ACTB_HUMAN (4-377): 0: 599: 94.12		EP400_HUMAN (1085-1716): 1.74e-11: 73: 13.39
+	Hs
		929972 ACTG_HUMAN (4-377): 0: 599: 94.39		EP400_HUMAN (1085-1716): 1.74e-11: 73: 13.39
+	Hs
		932332 ACTC_HUMAN (1-377): 0: 599: 100.00		EP400_HUMAN (1085-1716): 1.74e-11: 73: 13.39
+	Mm
		929795 ACTG_MOUSE (4-377): 0: 599: 94.39		SMCA2_MOUSE (1470-1772): 2.76e-10: 68.8: 11.84
+	Mm
		929800 ACTG_MOUSE (4-377): 0: 599: 94.39		EP400_MOUSE (1024-1716): 9.22e-10: 67.2: 13.77
+	Mm
		929785 ACTG_MOUSE (4-377): 0: 599: 94.39		SMCA4_MOUSE (1022-1379): 7.86e-09: 64.2: 11.67
+	Hs
		846742 ACTC_HUMAN (1-377): 0: 599: 100.00		SMCA2_HUMAN (1477-1770): 8.82e-09: 63.8: 11.91