HitPredict

Interactor 1: ACTC (P68032)
Actin, alpha cardiac muscle 1 (EC 3.6.4.-) (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form]
Gene: ACTC1

Interactor 2: SH3K1 (Q96B97)
SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1)
Gene: SH3KBP1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	17606992
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005925 - focal adhesion GO:0007015 - actin filament organization
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 377 Hs			1 665
+	Hs
		892142 ACTB_HUMAN (4-377): 0: 599: 94.12		CD2AP_HUMAN (1-664): 1.16e-98: 317: 32.22
+	Hs
		932478 ACTC_HUMAN (1-377): 0: 599: 100.00		CD2AP_HUMAN (1-664): 1.16e-98: 317: 32.22
+	Hs
		891671 ACTB_HUMAN (4-377): 0: 599: 94.12		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		924453 ACTG_HUMAN (4-377): 0: 599: 94.39		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		924456 ACTC_HUMAN (1-377): 0: 599: 100.00		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		924454 ACTH_HUMAN (4-377): 0: 591: 98.93		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		933003 ACTS_HUMAN (1-377): 0: 599: 98.94		DNMBP_HUMAN (104-607): 3.03e-16: 85.1: 15.82
+	Hs
		235496 ACTS_HUMAN (1-377): 0: 599: 98.94		VINEX_HUMAN (67-445): 2.37e-15: 81.7: 19.82
+	Hs
		548675 ACTA_HUMAN (1-377): 0: 596: 98.41		VAV_HUMAN (84-158): 4.66e-13: 74.7: 28.95
+	Hs
		891821 ACTB_HUMAN (4-377): 0: 599: 94.12		SH319_HUMAN (164-469): 4.12e-09: 61.9: 13.31