HitPredict

Interactor 1: ACTC (P68032)
Actin, alpha cardiac muscle 1 (EC 3.6.4.-) (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form]
Gene: ACTC1

Interactor 2: LIMA1 (Q9UHB6)
LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm)
Gene: LIMA1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.643

Property	Details
Experiments	30890647, 34349018, 26496610
Identification Methods	affinity chromatography technology, proximity labelling technology, cross-linking study, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005925 - focal adhesion
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 377 Hs			1 759
+	Hs
		892091 ACTB_HUMAN (4-377): 0: 599: 94.12		LIMA1_HUMAN (1-759): 0: 855: 100.00
+	Hs
		930041 ACTG_HUMAN (4-377): 0: 599: 94.39		LIMA1_HUMAN (1-759): 0: 855: 100.00
+	Hs
		933070 ACTS_HUMAN (1-377): 0: 599: 98.94		LIMA1_HUMAN (1-759): 0: 855: 100.00
+	Hs
		915531 ACTA_HUMAN (1-377): 0: 596: 98.41		LIMA1_HUMAN (1-759): 0: 855: 100.00
+	Hs
		891887 ACTB_HUMAN (4-377): 0: 599: 94.12		MILK2_HUMAN (295-569): 1.42e-37: 153: 22.95
+	Hs
		929877 ACTG_HUMAN (4-377): 0: 599: 94.39		CSRP2_HUMAN (254-450): 3.35e-41: 151: 18.27
+	Mm
		915552 ACTA_MOUSE (1-377): 0: 596: 98.41		LASP1_MOUSE (389-572): 7.66e-39: 146: 18.27
+	Hs
		150545 ACTB_HUMAN (4-377): 0: 599: 94.12		ABLM1_HUMAN (298-548): 8.97e-23: 106: 11.28
+	Hs
		150554 ACTG_HUMAN (4-377): 0: 599: 94.39		ABLM1_HUMAN (298-548): 8.97e-23: 106: 11.28
+	Hs
		932996 ACTS_HUMAN (1-377): 0: 599: 98.94		ABLM2_HUMAN (369-647): 1.72e-22: 104: 11.79
+	Dm
		501502 ACT1_DROME (1-377): 0: 598: 94.43		MICAL_DROME (371-515): 6.96e-12: 71.8: 24.83
+	Hs
		891770 ACTB_HUMAN (4-377): 0: 599: 94.12		LASP1_HUMAN (390-480): 2.66e-11: 66.8: 25.00
+	Mm
		915554 ACTA_MOUSE (1-377): 0: 596: 98.41		PDLI5_MOUSE (310-441): 9.18e-11: 67.3: 19.55