HitPredict

Interactor 1: UB2L3 (P68036)
Ubiquitin-conjugating enzyme E2 L3 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme L3) (L-UBC) (UbcH7) (Ubiquitin carrier protein L3) (Ubiquitin-conjugating enzyme E2-F1) (Ubiquitin-protein ligase L3)
Gene: UBE2L3

Interactor 2: TRIPC (Q14669)
E3 ubiquitin-protein ligase TRIP12 (EC 2.3.2.26) (E3 ubiquitin-protein ligase for Arf) (ULF) (HECT-type E3 ubiquitin transferase TRIP12) (Thyroid receptor-interacting protein 12) (TR-interacting protein 12) (TRIP-12)
Gene: TRIP12

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	1.00	0.888

Property	Details
Experiments	29643511, 32755579, 33567268, 9575161
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	HECT~UQ_con
Common GO terms	GO:0000209 - protein polyubiquitination GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 154 Hs			1 1992
+	Hs
		1056647 UB2D4_HUMAN (2-149): 6.75e-76: 224: 38.93		TRIPC_HUMAN (1-1992): 0: 1579: 100.00
+	Hs
		919729 UB2D2_HUMAN (2-149): 7.95e-75: 221: 37.58		TRIPC_HUMAN (1-1992): 0: 1579: 100.00
+	Hs
		125808 UB2D4_HUMAN (2-149): 6.75e-76: 224: 38.93		WWP2_HUMAN (1053-1990): 0: 603: 18.31
+	Hs
		125335 UB2D2_HUMAN (2-149): 7.95e-75: 221: 37.58		WWP2_HUMAN (1053-1990): 0: 603: 18.31
+	Hs
		1294888 UB2D4_HUMAN (2-149): 6.75e-76: 224: 38.93		ITCH_HUMAN (1018-1990): 0: 591: 17.29
+	Hs
		919827 UB2D2_HUMAN (2-149): 7.95e-75: 221: 37.58		ITCH_HUMAN (1018-1990): 0: 591: 17.29
+	Hs
		919834 UB2D2_HUMAN (2-149): 7.95e-75: 221: 37.58		NED4L_HUMAN (989-1990): 0: 588: 16.37
+	Hs
		919860 UB2D2_HUMAN (2-149): 7.95e-75: 221: 37.58		WWP1_HUMAN (1038-1990): 0: 580: 16.88
+	Hs
		919867 UB2D2_HUMAN (2-149): 7.95e-75: 221: 37.58		SMUF2_HUMAN (1373-1989): 2.4e-168: 535: 19.18
+	Hs
		808078 UB2D2_HUMAN (2-149): 7.95e-75: 221: 37.58		NEDD4_HUMAN (814-1990): 2.08e-159: 528: 13.49
+	Sc
		549815 UBC4_YEAST (1-148): 8.58e-75: 221: 40.27		RSP5_YEAST (1422-1990): 3.6e-164: 525: 19.59
+	Hs
		919741 UB2D2_HUMAN (2-149): 7.95e-75: 221: 37.58		HERC4_HUMAN (1290-1991): 1.24e-156: 513: 18.47
+	Hs
		919869 UB2D2_HUMAN (2-149): 7.95e-75: 221: 37.58		SMUF1_HUMAN (1455-1989): 1.22e-158: 508: 18.46
+	Sc
		549823 UBC4_YEAST (1-148): 8.58e-75: 221: 40.27		HUL5_YEAST (1321-1992): 1.29e-147: 483: 20.12
+	Hs
		919782 UB2D2_HUMAN (2-149): 7.95e-75: 221: 37.58		HACE1_HUMAN (1402-1992): 1.1e-146: 480: 20.23
+	Hs
		919710 UB2D2_HUMAN (2-149): 7.95e-75: 221: 37.58		UBE3A_HUMAN (1492-1991): 2.41e-140: 462: 27.02
+	Hs
		1357018 UB2D4_HUMAN (2-149): 6.75e-76: 224: 38.93		HECD1_HUMAN (437-1230): 6.18e-77: 287: 15.52
+	Sc
		549801 UBC4_YEAST (1-148): 8.58e-75: 221: 40.27		UFD4_YEAST (351-962): 4.64e-35: 149: 17.31
+	Hs
		919732 UB2D2_HUMAN (2-149): 7.95e-75: 221: 37.58		UBE3C_HUMAN (1697-1992): 3.54e-26: 119: 30.57
+	Hs
		919765 UB2D2_HUMAN (2-149): 7.95e-75: 221: 37.58		HUWE1_HUMAN (1616-1992): 2.18e-25: 118: 28.72