HitPredict

Interactor 1: UB2L3 (P68036)
Ubiquitin-conjugating enzyme E2 L3 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme L3) (L-UBC) (UbcH7) (Ubiquitin carrier protein L3) (Ubiquitin-conjugating enzyme E2-F1) (Ubiquitin-protein ligase L3)
Gene: UBE2L3

Interactor 2: UBA5 (Q9GZZ9)
Ubiquitin-like modifier-activating enzyme 5 (Ubiquitin-activating enzyme 5) (ThiFP1) (UFM1-activating enzyme) (Ubiquitin-activating enzyme E1 domain-containing protein 1)
Gene: UBA5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	29643511
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	ThiF~UQ_con
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 154 Hs			1 404
+	Hs
		919856 UB2D2_HUMAN (2-149): 7.95e-75: 221: 37.58		UBA5_HUMAN (1-404): 1.8e-151: 436: 100.00
+	Hs
		919796 UB2D2_HUMAN (2-149): 7.95e-75: 221: 37.58		UBA3_HUMAN (6-247): 2.13e-65: 217: 19.77
+	Hs
		1282360 UB2E3_HUMAN (2-149): 2.39e-68: 207: 34.90		SAE2_HUMAN (57-233): 2.97e-53: 189: 26.40
+	Sc
		600929 UBC1_YEAST (1-150): 3.77e-26: 100: 34.87		UBA4_YEAST (9-337): 9.77e-91: 282: 18.13
+	Hs
		607190 UB2D4_HUMAN (2-149): 6.75e-76: 224: 38.93		UBA1_HUMAN (20-218): 5.28e-32: 130: 13.15
+	Hs
		607026 UB2D1_HUMAN (2-149): 5.66e-75: 221: 38.26		UBA1_HUMAN (20-218): 5.28e-32: 130: 13.15
+	Hs
		607050 UB2D2_HUMAN (2-149): 7.95e-75: 221: 37.58		UBA1_HUMAN (20-218): 5.28e-32: 130: 13.15
+	Hs
		607039 UB2D3_HUMAN (2-149): 8.29e-74: 218: 36.91		UBA1_HUMAN (20-218): 5.28e-32: 130: 13.15
+	Sc
		549788 UBC4_YEAST (1-148): 8.58e-75: 221: 40.27		UBA1_YEAST (44-218): 2.65e-27: 116: 19.21
+	Hs
		607129 UB2E3_HUMAN (2-149): 2.39e-68: 207: 34.90		UBA1_HUMAN (20-218): 5.28e-32: 130: 13.15
+	Hs
		607136 UB2E2_HUMAN (2-149): 1.55e-68: 207: 34.90		UBA1_HUMAN (20-218): 5.28e-32: 130: 13.15
+	Sp
		293848 UBC4_SCHPO (2-148): 1.36e-73: 218: 37.84		UBA1_SCHPO (35-300): 2e-27: 116: 13.11
+	Hs
		607028 UB2E1_HUMAN (2-149): 6.55e-67: 203: 34.90		UBA1_HUMAN (20-218): 5.28e-32: 130: 13.15
+	Hs
		607023 UBE2A_HUMAN (3-150): 7.79e-65: 196: 26.17		UBA1_HUMAN (20-218): 5.28e-32: 130: 13.15
+	Hs
		607057 UB2L3_HUMAN (1-154): 1.26e-64: 196: 100.00		UBA1_HUMAN (20-218): 5.28e-32: 130: 13.15
+	Hs
		607054 UBE2B_HUMAN (3-148): 8.21e-64: 193: 26.53		UBA1_HUMAN (20-218): 5.28e-32: 130: 13.15
+	Hs
		159017 UB2L6_HUMAN (1-152): 4e-53: 166: 55.26		UBA1_HUMAN (20-218): 5.28e-32: 130: 13.15
+	Hs
		607169 UBE2T_HUMAN (43-151): 2.92e-25: 97.1: 40.18		UBA1_HUMAN (20-218): 5.28e-32: 130: 13.15
+	Sp
		293851 UBC14_SCHPO (7-149): 2.42e-28: 103: 36.11		UBA1_SCHPO (35-300): 2e-27: 116: 13.11
+	Sc
		600919 UBC1_YEAST (1-150): 3.77e-26: 100: 34.87		UBA1_YEAST (44-218): 2.65e-27: 116: 19.21