HitPredict

Interactor 1: UB2L3 (P68036)
Ubiquitin-conjugating enzyme E2 L3 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme L3) (L-UBC) (UbcH7) (Ubiquitin carrier protein L3) (Ubiquitin-conjugating enzyme E2-F1) (Ubiquitin-protein ligase L3)
Gene: UBE2L3

Interactor 2: HECD1 (Q9ULT8)
E3 ubiquitin-protein ligase HECTD1 (EC 2.3.2.26) (E3 ligase for inhibin receptor) (EULIR) (HECT domain-containing protein 1)
Gene: HECTD1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.80	0.579

Property	Details
Experiments	29643511
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	HECT~UQ_con
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 154 Hs			1 2610
+	Hs
		1357018 UB2D4_HUMAN (2-149): 6.75e-76: 224: 38.93		HECD1_HUMAN (1-2610): 0: 2419: 100.00
+	Hs
		919762 UB2D2_HUMAN (2-149): 7.95e-75: 221: 37.58		HECW1_HUMAN (1637-2609): 3.58e-129: 450: 14.66
+	Sc
		549801 UBC4_YEAST (1-148): 8.58e-75: 221: 40.27		UFD4_YEAST (2031-2610): 2.7e-129: 448: 28.16
+	Hs
		919889 UB2D2_HUMAN (2-149): 7.95e-75: 221: 37.58		HECW2_HUMAN (1360-2609): 2.26e-127: 444: 14.40
+	Hs
		304110 UB2D2_HUMAN (2-149): 7.95e-75: 221: 37.58		UBR5_HUMAN (1985-2609): 1.07e-116: 418: 16.94
+	Hs
		1294888 UB2D4_HUMAN (2-149): 6.75e-76: 224: 38.93		ITCH_HUMAN (2234-2608): 3.18e-117: 398: 21.88
+	Hs
		919834 UB2D2_HUMAN (2-149): 7.95e-75: 221: 37.58		NED4L_HUMAN (2255-2608): 4.26e-117: 399: 21.67
+	Hs
		919827 UB2D2_HUMAN (2-149): 7.95e-75: 221: 37.58		ITCH_HUMAN (2234-2608): 3.18e-117: 398: 21.88
+	Sc
		549823 UBC4_YEAST (1-148): 8.58e-75: 221: 40.27		HUL5_YEAST (2050-2610): 8.38e-117: 397: 18.66
+	Hs
		919867 UB2D2_HUMAN (2-149): 7.95e-75: 221: 37.58		SMUF2_HUMAN (2235-2607): 4.78e-118: 395: 20.62
+	Hs
		919869 UB2D2_HUMAN (2-149): 7.95e-75: 221: 37.58		SMUF1_HUMAN (2220-2607): 1.5e-116: 391: 19.70
+	Hs
		125808 UB2D4_HUMAN (2-149): 6.75e-76: 224: 38.93		WWP2_HUMAN (2265-2608): 1.64e-107: 368: 24.86
+	Hs
		125335 UB2D2_HUMAN (2-149): 7.95e-75: 221: 37.58		WWP2_HUMAN (2265-2608): 1.64e-107: 368: 24.86
+	Sc
		549815 UBC4_YEAST (1-148): 8.58e-75: 221: 40.27		RSP5_YEAST (2265-2608): 2.06e-105: 360: 20.86
+	Hs
		919860 UB2D2_HUMAN (2-149): 7.95e-75: 221: 37.58		WWP1_HUMAN (2328-2608): 5.47e-91: 321: 29.27
+	Hs
		1056647 UB2D4_HUMAN (2-149): 6.75e-76: 224: 38.93		TRIPC_HUMAN (5-1083): 4.48e-58: 225: 14.03
+	Hs
		919729 UB2D2_HUMAN (2-149): 7.95e-75: 221: 37.58		TRIPC_HUMAN (5-1083): 4.48e-58: 225: 14.03
+	Hs
		919710 UB2D2_HUMAN (2-149): 7.95e-75: 221: 37.58		UBE3A_HUMAN (2406-2607): 5.17e-25: 116: 34.95
+	Hs
		919732 UB2D2_HUMAN (2-149): 7.95e-75: 221: 37.58		UBE3C_HUMAN (2405-2610): 9.09e-23: 109: 32.37
+	Hs
		919782 UB2D2_HUMAN (2-149): 7.95e-75: 221: 37.58		HACE1_HUMAN (204-449): 1.11e-20: 102: 14.96